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oxyMORphone HCl ER

Oxymorphone HCl ER is an opioid analgesic used for the management of chronic pain in patients requiring continuous, long-term opioid treatment. The extended-release formulation allows for controlled release of medication over an extended period, typically providing pain relief for up to 12 hours.

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Frequently Asked Questions

How quickly does Oxymorphone HCl ER work?
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Oxymorphone HCl ER typically starts to provide pain relief within 1 to 2 hours, with peak effects occurring around 3 to 4 hours after administration.

Can I take Oxymorphone HCl ER with food?
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Yes, it can be taken with or without food; however, taking it consistently the same way may help with absorption.

hat should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Are there any dietary restrictions while using Oxymorphone HCl ER?
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There are no specific dietary restrictions, but avoiding alcohol is crucial.

Is Oxymorphone HCl ER safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Oxymorphone HCl ER during these periods.

Comprehensive Drug Guide

How Does oxyMORphone HCl ER Work?

Oxymorphone works by binding to opioid receptors in the brain and spinal cord, altering the perception of pain and emotional response to pain. This interaction results in pain relief and a sense of euphoria.

What is oxyMORphone HCl ER Used For?


Common Dosages

  • Extended-Release Tablets: Common strengths include 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, and 40 mg.

Typical Dosing

  • The dosing regimen is individualized based on the patient’s pain severity and previous opioid exposure. The usual starting dose for opioid-tolerant patients may begin at 5 mg to 10 mg every 12 hours, while opioid-naïve patients should start at a lower dose, typically 5 mg every 12 hours.


Typical Dosing

FDA Approved Indications

  • Management of Chronic Pain: for patients requiring continuous opioid analgesia.

Who Shouldn't Take oxyMORphone HCl ER?

  • Known hypersensitivity to oxymorphone or any component of the formulation.
  • Severe respiratory depression or acute asthma.
  • Paralytic ileus.


Advice From The Pharmacist

  • Take Oxymorphone HCl ER exactly as prescribed; do not crush or chew the tablets, as this can lead to a dangerous increase in the release of the drug.
  • Avoid alcohol and other central nervous system depressants, as these can enhance the sedative effects and increase the risk of respiratory depression.
  • Regular follow-ups with your healthcare provider are important to evaluate pain control and monitor for signs of misuse or dependence.


Side Effects of oxyMORphone HCl ER

Common Side Effects

  • Drowsiness
  • Constipation
  • Nausea
  • Vomiting
  • Dizziness


Uncommon/Severe Side Effects

  • Respiratory depression (slow or shallow breathing)
  • Severe allergic reactions (rash, itching, swelling)
  • Signs of overdose (confusion, extreme drowsiness, slow heart rate).


Risks and Warnings of oxyMORphone HCl ER

  • Risk of Addiction: Oxymorphone has a potential for abuse and addiction, especially in individuals with a history of substance use disorder.
  • Respiratory Depression: Monitor for signs of respiratory depression, particularly when starting therapy or increasing the dose.

Interactions with oxyMORphone HCl ER

Common Drug Interactions

  • Other Opioids: Use with caution when combining with other opioids to avoid excessive sedation and respiratory depression.
  • CNS Depressants: Monitor for additive effects when used with benzodiazepines, alcohol, or muscle relaxants.


Alternatives to oxyMORphone HCl ER

  • Other Opioid Analgesics: Such as morphine or hydromorphone for chronic pain management.
  • Non-Opioid Analgesics: Such as acetaminophen or NSAIDs for less severe pain.