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Oxlumo
Oxlumo (lumasiran) is a small interfering RNA (siRNA) therapy indicated for the treatment of primary hyperoxaluria type 1 (PH1), a rare genetic disorder that leads to excessive production of oxalate, resulting in kidney stones, nephrocalcinosis, and potentially kidney failure. Oxlumo works by reducing the production of oxalate in the liver, thereby lowering oxalate levels in the bloodstream and urine.
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Frequently Asked Questions
How quickly does Oxlumo start to work?
Patients may begin to see a reduction in urinary oxalate levels within a few weeks of starting treatment, but it may take longer to assess the full benefits.
Can I stop taking Oxlumo suddenly?
It is important to continue Oxlumo as prescribed. Consult your healthcare provider before making any changes to your treatment regimen.
Are there any specific dietary restrictions while using Oxlumo?
There are no specific dietary restrictions associated with Oxlumo, but patients should discuss their diet with their healthcare provider, particularly concerning oxalate intake.
What should I do if I miss a dose of Oxlumo?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Oxlumo safe for long-term use?
Oxlumo is intended for long-term management of PH1. Regular follow-ups with your healthcare provider are important to monitor treatment effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Oxlumo Work?
Lumasiran functions by targeting and degrading the mRNA that encodes glyoxylate reductase/hydroxypyruvate reductase (GRHPR), an enzyme involved in the conversion of glyoxylate to glycolate. By inhibiting the production of this enzyme, Oxlumo decreases the hepatic synthesis of oxalate, leading to reduced oxalate levels in the body.
Common Dosages
- Injection: 6 mg/mL solution for subcutaneous administration.
Typical Dosing
- The recommended dosing schedule for Oxlumo is an initial dose of 3 mg/kg given subcutaneously once every month for the first 3 months, followed by a maintenance dose of 3 mg/kg once every three months thereafter.
Typical Dosing
FDA Approved Indications
- Treatment of primary hyperoxaluria type 1 (PH1) in pediatric and adult patients.
Who Shouldn't Take Oxlumo?
Known hypersensitivity to lumasiran or any components of the formulation.
Advice From The Pharmacist
- Instruct patients to administer Oxlumo exactly as prescribed and to follow the dosing schedule for optimal effectiveness.
- Advise patients about the proper technique for subcutaneous injection and to rotate injection sites to minimize irritation.
- Encourage patients to report any signs of injection site reactions, allergic reactions, or unusual symptoms to their healthcare provider.
Side Effects of Oxlumo
Common Side Effects
- Injection site reactions (such as redness, swelling, or pain)
- Abdominal pain
- Nausea
- Fatigue
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
Risks and Warnings of Oxlumo
- Injection Site Reactions: Monitor patients for any severe reactions at the injection site, and provide guidance on how to manage these reactions.
- Hypersensitivity: Patients should be informed about the potential for hypersensitivity reactions and instructed to seek medical attention if symptoms occur.
Interactions with Oxlumo
Common Drug Interactions
- Other Medications: There are no known significant drug interactions specific to Oxlumo, but patients should inform their healthcare provider about all medications they are taking to ensure comprehensive care.
Alternatives to Oxlumo
- Other Treatments for Hyperoxaluria: While Oxlumo is specifically for PH1, other therapies for hyperoxaluria may include dietary modifications and medications to manage kidney stones, though they do not directly target the underlying cause like Oxlumo.
