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Oxervate
Oxervate (generic name: cenegermin-bkbj) is a recombinant human nerve growth factor used to treat neurotrophic keratitis, a rare eye disease that affects the cornea, leading to damage and vision problems. Oxervate helps to heal the cornea by promoting the regeneration of corneal nerves, which are crucial for maintaining the eye's health and integrity. It is one of the few treatments specifically designed to address the underlying nerve damage in neurotrophic keratitis.
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Frequently Asked Questions
How does Oxervate help treat neurotrophic keratitis?
Oxervate promotes the healing and regeneration of damaged corneal nerves, addressing the root cause of neurotrophic keratitis and helping the cornea to heal.
How does Oxervate help treat neurotrophic keratitis?
Oxervate promotes the healing and regeneration of damaged corneal nerves, addressing the root cause of neurotrophic keratitis and helping the cornea to heal.
How long will it take to see results with Oxervate?
Most patients begin to see improvements within the first few weeks of treatment, but it is important to complete the full 8-week course for optimal healing.
Can I wear contact lenses while using Oxervate?
You should remove contact lenses before applying Oxervate and wait 15 minutes before reinserting them to avoid interference with the medication.
Is Oxervate safe for long-term use?
Oxervate is typically used for a defined treatment period of 8 weeks. Long-term safety has not been established for continuous use beyond this period.
How should I store Oxervate?
Oxervate should be stored in the refrigerator and protected from light. Once removed from the refrigerator, the vials can be stored at room temperature for up to 12 hours.
Comprehensive Drug Guide
How Does Oxervate Work?
Oxervate works by mimicking nerve growth factor (NGF), a protein naturally found in the body that supports the growth and survival of nerve cells. When applied to the eye, cenegermin promotes the healing and regeneration of damaged corneal nerves, helping to restore corneal sensitivity and improve healing in patients with neurotrophic keratitis.
Common Dosages
- Ophthalmic solution (20 mcg/mL), provided in single-use vials.
Typical Dosing
- The typical dose of Oxervate is one drop in the affected eye(s) every 2 hours, six times a day for a period of 8 weeks.
- Each vial is for single-use only and should be discarded after administration.
Typical Dosing
FDA Approved Indications
- Neurotrophic keratitis: A rare degenerative disease of the cornea where the corneal nerves are damaged, leading to chronic non-healing corneal ulcers and vision loss.
Who Shouldn't Take Oxervate?
- Known hypersensitivity to cenegermin-bkbj or any of its components.
- Active ocular infections, as the infection should be treated before starting Oxervate.
Advice From The Pharmacist
- Store Oxervate in the refrigerator (2°C to 8°C) and protect it from light. Once removed from the refrigerator, the vials can be stored at room temperature (up to 25°C) for up to 12 hours.
- Oxervate is a single-use vial. Once a vial is opened and used, discard it immediately after administering the dose.
- Wash your hands thoroughly before and after using the eye drops to prevent contamination.
- If you wear contact lenses, remove them before applying Oxervate and wait 15 minutes before reinserting them.
- Follow the full 8-week treatment regimen as prescribed, even if symptoms improve before the course is completed.
Side Effects of Oxervate
Common Side Effects
- Eye pain or discomfort
- Eye redness
- Tearing
- Blurred vision
- Sensation of a foreign object in the eye
Uncommon/Severe Side Effects
- Severe allergic reactions such as swelling or hives
- Worsening corneal conditions if used improperly
Risks and Warnings of Oxervate
- Risk of Infection: Proper hygiene is crucial when administering Oxervate to prevent contamination that can lead to eye infections. Ensure that the dropper does not touch your eye or any surface.
- Temporary Eye Discomfort: Some patients may experience temporary discomfort, such as burning or stinging after applying the drops. If the pain persists, contact your doctor.
Interactions with Oxervate
Common Drug Interactions
Oxervate does not have any significant systemic interactions due to its local application in the eye. However, patients using multiple ophthalmic medications should consult their healthcare provider on the proper timing and order of administration to avoid potential interactions between products.
Alternatives to Oxervate
- Conventional treatments: Such as artificial tears and eye drops to manage the symptoms of neurotrophic keratitis, though these do not address the underlying nerve damage.
- Autologous serum eye drops: A specialized treatment made from a patient's own blood to help heal corneal damage.
- Scleral contact lenses: Special lenses used to protect and support healing in the cornea.
