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Otrexup
Otrexup (methotrexate) is an injectable medication primarily used in the treatment of rheumatoid arthritis, psoriasis, and certain types of cancer. It is an antimetabolite that interferes with the growth of rapidly dividing cells, including immune cells involved in inflammatory processes. Otrexup is specifically formulated for subcutaneous injection, allowing for convenient self-administration.
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Frequently Asked Questions
How quickly will I see results with Otrexup?
Patients may begin to notice improvements in their symptoms within several weeks, but optimal results can take longer depending on the condition being treated.
Can I take Otrexup with food?
Otrexup can be taken with or without food; however, consistent administration at the same time each week is recommended.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember on the same day. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is it safe to use Otrexup during pregnancy?
Otrexup should not be used during pregnancy due to the risk of serious harm to the fetus. Consult your healthcare provider for alternative treatments.
What are the signs of serious side effects to watch for?
Monitor for signs of infection, liver dysfunction (jaundice, abdominal pain), or severe allergic reactions, and contact your healthcare provider immediately if these occur.
Comprehensive Drug Guide
How Does Otrexup Work?
Otrexup works by inhibiting the enzyme dihydrofolate reductase, which is essential for the synthesis of DNA and RNA. This action disrupts the proliferation of immune cells and reduces inflammation, thereby alleviating symptoms of autoimmune diseases such as rheumatoid arthritis and psoriasis. It also affects the growth of cancer cells, making it useful in certain oncology protocols.
Common Dosages
- Injectable solution: 7.5 mg, 10 mg, 12.5 mg, 15 mg, and 20 mg.
Typical Dosing
- Adults with rheumatoid arthritis: The typical starting dose is 7.5 mg to 15 mg once weekly, with adjustments based on clinical response and tolerance.
- Adults with psoriasis: The usual starting dose is similar, often adjusted based on the severity of the condition and individual response.
Typical Dosing
FDA Approved Indications
- Treatment of rheumatoid arthritis in adults.
- Treatment of severe psoriasis in adults.
- Treatment of certain types of cancer, including acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Who Shouldn't Take Otrexup?
- Known hypersensitivity to methotrexate or any component of the formulation
- Pregnancy or breastfeeding (due to potential harm to the fetus)
- Active infections
- Severe liver disease or renal impairment
Advice From The Pharmacist
- Administer Otrexup exactly as prescribed; do not alter the dosing schedule without consulting your healthcare provider.
- Rotate injection sites to minimize irritation and tissue damage.
- Monitor for side effects, especially signs of infection or liver dysfunction, and report any concerns to your healthcare provider.
Side Effects of Otrexup
Common Side Effects
- Nausea or vomiting
- Fatigue
- Mouth sores
- Hair loss
Uncommon/Severe Side Effects
- Liver damage (elevated liver enzymes)
- Bone marrow suppression (low blood cell counts)
- Severe allergic reactions (rash, itching, swelling)
Risks and Warnings of Otrexup
- Infection Risk: Otrexup can suppress the immune system, increasing the risk of infections; monitor for signs of infection and seek medical attention if needed.
- Liver Function: Regular monitoring of liver function tests is important due to the risk of hepatotoxicity.
- Pregnancy Risks: Methotrexate is teratogenic; effective contraception is recommended during treatment and for a period after discontinuation.
Interactions with Otrexup
Common Drug Interactions
- Other Immunosuppressants: Use with caution when combined with other medications that affect the immune system.
- NSAIDs and Salicylates: These can enhance the toxicity of methotrexate and should be used carefully.
- Live Vaccines: Avoid live vaccines during treatment due to immunosuppressive effects.
Alternatives to Otrexup
- Other DMARDs: Such as sulfasalazine or leflunomide for rheumatoid arthritis.
- Biologic Treatments: Such as TNF inhibitors or IL-6 inhibitors for similar indications.
