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Opzelura
Opzelura (ruxolitinib) is a topical Janus kinase (JAK) inhibitor used for the treatment of atopic dermatitis (eczema) in patients aged 12 years and older. It helps reduce inflammation and alleviate symptoms associated with this chronic skin condition.
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Frequently Asked Questions
How quickly does Opzelura work?
Patients may begin to notice improvements in their skin condition within a few weeks, but optimal results may take longer.
Can I use Opzelura with other topical medications?
Yes, but consult your healthcare provider about the appropriate sequence of application to avoid potential interactions.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule.
Is Opzelura safe during pregnancy?
Consult your healthcare provider before using Opzelura during pregnancy to evaluate potential risks and benefits.
What are the signs of serious side effects to watch for?
Monitor for signs of severe allergic reactions or infections, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Opzelura Work?
Ruxolitinib works by inhibiting the activity of Janus kinases, which play a crucial role in the signaling pathways of various cytokines involved in the inflammatory response. By blocking these pathways, Opzelura reduces inflammation and helps improve skin condition in patients with atopic dermatitis.
Common Dosages
- Topical cream: Concentration of 1.5%.
Typical Dosing
- Adults and Adolescents (12 years and older): Apply a thin layer of Opzelura cream to the affected areas of skin twice daily.
Typical Dosing
FDA Approved Indications
- Treatment of atopic dermatitis in patients aged 12 years and older.
Who Shouldn't Take Opzelura?
- Known hypersensitivity to ruxolitinib or any component of the formulation.
- Active infections, particularly those that are systemic or severe.
Advice From The Pharmacist
- Apply Opzelura exactly as prescribed, and avoid using it on broken or infected skin.
- Wash your hands after applying the cream to prevent unintended contact with other areas of skin.
- Monitor for any signs of infection or worsening of skin conditions, and report these to your healthcare provider.
Side Effects of Opzelura
Common Side Effects
- Application site reactions (itching, redness, burning)
- Headache
- Upper respiratory infections
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Increased risk of infections due to immune modulation.
Risks and Warnings of Opzelura
- Infection Risk: Patients should be monitored for signs of infection, as JAK inhibitors can suppress the immune response.
- Skin Reactions: Report any severe skin reactions to your healthcare provider promptly.
Interactions with Opzelura
Common Drug Interactions
- Immunosuppressive Medications: Inform your healthcare provider about all medications you are taking, especially other immunomodulatory agents, to avoid potential interactions.
Alternatives to Opzelura
- Other Topical Treatments: Such as corticosteroids or calcineurin inhibitors for managing atopic dermatitis.
- Systemic Treatments: In more severe cases, other systemic therapies like systemic corticosteroids or biologics may be considered.
