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Onexton
Onexton is a topical gel that combines benzoyl peroxide and clindamycin phosphate. It is primarily used for the treatment of acne vulgaris in patients aged 12 years and older. This combination works to reduce acne-causing bacteria and decrease inflammation in the skin.
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Frequently Asked Questions
How quickly does Onexton work?
Patients may start to see improvements in their acne within a few weeks, but optimal results typically take several weeks to months.
Can I use Onexton with other acne medications?
Consult your healthcare provider before combining Onexton with other acne treatments to avoid potential interactions or increased irritation.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it’s almost time for your next application, skip the missed dose and continue with your regular schedule.
Is Onexton safe during pregnancy?
Consult your healthcare provider before using Onexton during pregnancy to evaluate potential risks and benefits.
What are the signs of serious side effects to watch for?
Monitor for signs of severe allergic reactions or gastrointestinal issues, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Onexton Work?
- Benzoyl Peroxide: An antimicrobial agent that helps reduce the number of acne-causing bacteria (Propionibacterium acnes) and has a keratolytic effect, helping to unclog pores.
- Clindamycin Phosphate: An antibiotic that inhibits bacterial protein synthesis, further reducing inflammation and bacterial growth in acne.
Common Dosages
- Topical gel: Commonly in a concentration of 1.2% benzoyl peroxide and 1% clindamycin phosphate.
Typical Dosing
- Adults and Adolescents: The usual recommended dose is to apply a thin layer of the gel to the affected area once daily, preferably in the evening.
Typical Dosing
FDA Approved Indications
- Treatment of acne vulgaris in patients 12 years and older.
Who Shouldn't Take Onexton?
- Known hypersensitivity to benzoyl peroxide, clindamycin, or any component of the formulation.
- A history of antibiotic-associated colitis.
Advice From The Pharmacist
- Use Onexton exactly as prescribed and apply only to clean, dry skin.
- Avoid contact with eyes, mouth, and mucous membranes. If contact occurs, rinse thoroughly with water.
- Monitor for skin irritation, and if severe irritation occurs, discontinue use and consult your healthcare provider.
Side Effects of Onexton
Common Side Effects
- Skin irritation (redness, peeling, dryness)
- Burning or stinging sensation
- Itching
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Persistent diarrhea or gastrointestinal issues (related to clindamycin)
Risks and Warnings of Onexton
- Skin Sensitivity: Use with caution in patients with sensitive skin or eczema, as benzoyl peroxide may cause irritation.
- Sun Sensitivity: Benzoyl peroxide can increase sensitivity to sunlight; use sunscreen and protective clothing while using this medication.
Interactions with Onexton
Common Drug Interactions
- Other Topical Treatments: Inform your healthcare provider about other topical medications you are using to avoid increased irritation.
- Oral Antibiotics: Be cautious if using other antibiotics, especially clindamycin, to prevent possible overuse.
Alternatives to Onexton
- Other Topical Treatments: Such as retinoids (e.g., tretinoin) or other combinations of benzoyl peroxide with different antibiotics.
- Systemic Medications: For more severe cases, oral antibiotics or hormonal therapies may be considered.
