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Nymyo
Nymyo is a biologic medication used to treat moderate to severe ulcerative colitis, Crohn’s disease, and plaque psoriasis. It belongs to the class of integrin receptor antagonists, a type of monoclonal antibody that works by blocking specific immune cell interactions that cause inflammation in the gut and skin. Nymyo helps reduce symptoms such as abdominal pain, diarrhea, and skin plaque formation, improving the overall quality of life for patients with autoimmune conditions.
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Frequently Asked Questions
How long does it take for Nymyo to start working?
Most patients begin to see improvements in their symptoms within the first 2-6 weeks after starting treatment.
Can Nymyo be self-administered?
No, Nymyo must be administered as an intravenous infusion in a healthcare setting by a trained professional.
What should I do if I miss a scheduled infusion of Nymyo?
If you miss a scheduled infusion, contact your healthcare provider as soon as possible to reschedule. It’s important to maintain regular dosing for the medication to remain effective.
Are there any dietary restrictions while taking Nymyo?
There are no specific dietary restrictions while taking Nymyo. However, maintaining a balanced diet can help manage symptoms of inflammatory bowel diseases.
Can I receive vaccines while on Nymyo?
You should avoid live vaccines while on Nymyo, but inactivated vaccines (such as the flu shot) are generally safe. Always consult your healthcare provider before receiving any vaccinations.
Comprehensive Drug Guide
How Does Nymyo Work?
Nymyo works by targeting and blocking integrins, proteins that allow immune cells to travel to the site of inflammation in the gut or skin. By inhibiting this process, Nymyo reduces inflammation and prevents the immune system from attacking healthy tissues. This helps manage symptoms of ulcerative colitis, Crohn’s disease, and plaque psoriasis by reducing immune cell migration and inflammatory responses.
Common Dosages
- Intravenous infusion: Dosage is weight-based and typically administered every 4-8 weeks, depending on the condition.
Typical Dosing
- For ulcerative colitis and Crohn’s disease: The typical starting dose is an infusion at weeks 0, 2, and 6, followed by maintenance infusions every 8 weeks.
- For plaque psoriasis: The dosage schedule may vary, but it generally follows an infusion every 4-6 weeks after the initial loading doses.
Typical Dosing
FDA Approved Indications
- Moderate to severe ulcerative colitis
- Moderate to severe Crohn’s disease
- Plaque psoriasis
Who Shouldn't Take Nymyo?
- Known hypersensitivity to Nymyo or its components
- Active or chronic infections, particularly sepsis or tuberculosis
- Severe liver impairment
Advice From The Pharmacist
- Nymyo is administered as an intravenous infusion, which must be done in a healthcare setting under the supervision of a healthcare professional.
- Before starting Nymyo, patients should be screened for infections, including tuberculosis, and regularly monitored for signs of infection during treatment.
- Notify your healthcare provider if you experience any new or worsening symptoms, particularly signs of infection.
- Live vaccines should be avoided while receiving Nymyo.
Side Effects of Nymyo
Common Side Effects
- Headache
- Nausea
- Fatigue
- Infusion-related reactions (fever, chills, rash)
Uncommon/Severe Side Effects
- Severe infections, including tuberculosis and sepsis
- Liver problems (elevated liver enzymes)
- Allergic reactions (anaphylaxis)
Risks and Warnings of Nymyo
- Infection Risk: Since Nymyo suppresses parts of the immune system, it can increase the risk of serious infections. Patients should be monitored closely for signs of infection, including tuberculosis and sepsis.
- Liver Injury: Nymyo may cause liver damage in rare cases, and liver function should be monitored during treatment.
- Infusion Reactions: Some patients may experience infusion-related reactions, such as fever, chills, or rash, during or shortly after receiving the medication. These reactions should be reported to a healthcare provider immediately.
Interactions with Nymyo
Common Drug Interactions
- Live vaccines: Live vaccines should be avoided while on Nymyo, as the immune system may not respond effectively, or there may be an increased risk of infection.
- Immunosuppressive medications: Combining Nymyo with other immunosuppressants may increase the risk of infections.
Alternatives to Nymyo
- Entyvio (vedolizumab): Another integrin receptor antagonist used for Crohn’s disease and ulcerative colitis.
- Stelara (ustekinumab): A biologic targeting IL-12 and IL-23, used for Crohn’s disease and psoriasis.
- Remicade (infliximab): A TNF inhibitor used for Crohn’s disease, ulcerative colitis, and other autoimmune conditions.
- Humira (adalimumab): A TNF inhibitor used to treat inflammatory conditions, including Crohn’s disease and ulcerative colitis.
