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Nortrel 1/35 (21)

Nortrel 1/35 is a combination oral contraceptive that contains ethinyl estradiol and norethindrone. It is used primarily to prevent pregnancy and can also help regulate menstrual cycles and reduce menstrual-related symptoms.



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Frequently Asked Questions

How quickly does Nortrel 1/35 work?
Open FAQClose FAQ

Nortrel 1/35 is effective within 7 days if started during the first week of your menstrual cycle. If started at another time, use backup contraception for the first 7 days.

Can I take Nortrel 1/35 with food?
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Yes, Nortrel 1/35 can be taken with or without food.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. If you miss more than one dose, follow the instructions provided in the package insert or consult your healthcare provider.

Is Nortrel 1/35 safe during pregnancy?
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Nortrel 1/35 should not be taken during pregnancy. If you suspect you are pregnant, discontinue use and contact your healthcare provider.

What are the signs of serious side effects to watch for?
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Monitor for signs of severe allergic reactions, significant changes in mood, or symptoms of blood clots, and seek immediate medical attention if these occur.

Comprehensive Drug Guide

How Does Nortrel 1/35 (21) Work?

The hormones in Nortrel 1/35 work by inhibiting ovulation, altering the uterine lining to prevent implantation, and thickening cervical mucus to reduce sperm penetration. This combination of actions effectively prevents pregnancy.

Common Dosages

  • Tablets: Each pack contains 21 active tablets, with each tablet containing 1 mg of norethindrone and 0.035 mg of ethinyl estradiol.

Typical Dosing

  • Adults: The usual recommended dosage is to take one tablet daily at the same time each day for 21 days, followed by a 7-day break during which no pills are taken.


Typical Dosing

FDA Approved Indications

  • Prevention of pregnancy.


Who Shouldn't Take Nortrel 1/35 (21)?

  • Known hypersensitivity to norethindrone, ethinyl estradiol, or any component of the formulation.
  • History of thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism).
  • Certain cancers (e.g., breast cancer) or severe liver disease.


Advice From The Pharmacist

  • Take Nortrel 1/35 exactly as prescribed, and do not skip doses to ensure maximum effectiveness.
  • Monitor for any side effects, such as nausea, headache, or mood changes, and report these to your healthcare provider.
  • Consider using backup contraception (like condoms) if you miss a dose, especially during the first week of use.


Side Effects of Nortrel 1/35 (21)

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Mood changes
  • Weight gain


Uncommon/Severe Side Effects

  • Blood clots (symptoms may include swelling, pain, or redness in the legs)
  • Severe allergic reactions (rash, itching, swelling)


Risks and Warnings of Nortrel 1/35 (21)

  • Thromboembolic Events: Monitor for symptoms of blood clots, especially in women with additional risk factors (smoking, obesity).
  • Cancer Risk: Long-term use of hormonal contraceptives may increase the risk of certain types of cancers.


Interactions with Nortrel 1/35 (21)

Common Drug Interactions

  • Antibiotics: Some antibiotics may reduce the effectiveness of hormonal contraceptives.
  • Anticonvulsants: Certain seizure medications can affect how well Nortrel 1/35 works.


Alternatives to Nortrel 1/35 (21)

  • Other Hormonal Contraceptives: Such as other combination pills, patches, or vaginal rings for similar indications.
  • Non-hormonal Contraceptives: Such as condoms or copper intrauterine devices (IUDs).