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Northera
Northera (generic name: droxidopa) is a medication used to treat neurogenic orthostatic hypotension (NOH), a condition characterized by a significant drop in blood pressure when standing, which can lead to dizziness, lightheadedness, and fainting. Northera is converted into norepinephrine in the body, helping to increase blood pressure and improve symptoms associated with this condition.
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Frequently Asked Questions
How quickly does Northera work?
Patients may begin to notice improvements in symptoms within 1 to 2 hours of taking the medication.
Can I take Northera with food?
Yes, Northera can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Northera?
There are no specific dietary restrictions while using Northera.
Is Northera safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Northera during these periods.
Comprehensive Drug Guide
How Does Northera Work?
Droxidopa is a prodrug that is converted to norepinephrine, a neurotransmitter that causes blood vessels to constrict, thereby increasing blood pressure. This action helps alleviate symptoms of orthostatic hypotension by improving blood flow and stability when standing.
What is Northera Used For?
Common Dosages
- Capsules: 100 mg, 200 mg, and 300 mg.
Typical Dosing
- The usual starting dose is 100 mg three times daily, which may be increased based on patient response and tolerability, with a maximum dose of 600 mg per day.
Typical Dosing
FDA Approved Indications
- Neurogenic Orthostatic Hypotension: for the treatment of adult patients with NOH associated with conditions such as Parkinson's disease, multiple system atrophy, and pure autonomic failure.
Who Shouldn't Take Northera?
- Known hypersensitivity to droxidopa or any component of the formulation.
- History of pheochromocytoma (a type of tumor that can affect blood pressure).
Advice From The Pharmacist
- Take Northera exactly as prescribed, and do not exceed the recommended dosage.
- It can be taken with or without food, but consistency is important for absorption.
- Monitor blood pressure regularly, especially during the initial treatment period.
Side Effects of Northera
Common Side Effects
- Headache
- Nausea
- Dizziness
- Fatigue
- Increased blood pressure
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Worsening hypertension.
Risks and Warnings of Northera
- Blood Pressure Monitoring: Regular monitoring of blood pressure is essential, as droxidopa can cause increased blood pressure.
- Caution in Cardiac Conditions: Use with caution in patients with a history of cardiovascular disease, as it may exacerbate heart conditions.
Interactions with Northera
Common Drug Interactions
- Antihypertensive Medications: Droxidopa may interact with other blood pressure medications, necessitating close monitoring.
- MAO Inhibitors: Caution should be exercised when used in combination with MAO inhibitors due to potential hypertensive crises.
Alternatives to Northera
- Other Vasopressors: Such as midodrine for managing orthostatic hypotension.
- Non-pharmacological Approaches: Such as increased fluid intake, dietary changes, or compression garments.
