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Norlyroc
Norlyroc (naloxegol) is a medication used for the treatment of opioid-induced constipation (OIC) in adults with chronic pain who are also taking opioids. It is a peripherally acting mu-opioid receptor antagonist, which means it works by blocking the effects of opioids on the gut without affecting pain relief.
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Frequently Asked Questions
How quickly does Norlyroc start to work?
Patients may begin to notice improvements in bowel movements within 24 to 48 hours after starting Norlyroc.
Can I use Norlyroc while pregnant or breastfeeding?
Consult your healthcare provider before using Norlyroc if you are pregnant, planning to become pregnant, or breastfeeding to assess any potential risks.
Are there any specific dietary restrictions while using Norlyroc?
There are no specific dietary restrictions associated with the use of Norlyroc, but a balanced diet may help improve bowel function.
What should I do if I miss a dose of Norlyroc?
If you miss a dose, take it as soon as you remember, provided it is on the same day. If it's close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Norlyroc safe for long-term use?
Norlyroc can be safe for long-term use under medical supervision for managing opioid-induced constipation. Regular follow-ups with a healthcare provider are important to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Norlyroc Work?
Blocking opioid receptors in the gastrointestinal tract: Naloxegol selectively binds to mu-opioid receptors in the gut, which reduces the constipating effects of opioids while allowing the central analgesic effects to remain intact. This helps to relieve constipation caused by opioid use.
What is Norlyroc Used For?
Common Dosages
- Oral tablets: Common strength is 25 mg.
Typical Dosing
- The usual recommended dose is 25 mg taken orally once daily. In patients with renal impairment, the dose may be adjusted to 12.5 mg once daily.
Typical Dosing
FDA Approved Indications
- Treatment of opioid-induced constipation in adults with chronic pain.
Who Shouldn't Take Norlyroc?
- Known hypersensitivity to naloxegol or any components of the formulation.
- Severe gastrointestinal obstruction.
Advice From The Pharmacist
- Instruct patients to take Norlyroc on an empty stomach, at least 1 hour before or 2 hours after meals, to maximize absorption.
- Advise patients to monitor for signs of opioid withdrawal, as Norlyroc can precipitate withdrawal symptoms in patients dependent on opioids.
- Discuss potential side effects, including abdominal pain, diarrhea, and nausea, and encourage patients to report any severe or unusual symptoms.
Side Effects of Norlyroc
Common Side Effects
- Abdominal pain
- Diarrhea
- Nausea
- Vomiting
- Flatulence
Uncommon/Severe Side Effects
- Opioid withdrawal symptoms (such as body aches, sweating, and agitation).
- Severe allergic reactions (such as rash, itching, or difficulty breathing).
Risks and Warnings of Norlyroc
- Withdrawal Risk: Patients with opioid dependence should be monitored closely for signs of withdrawal, especially during the initial treatment phase.
- Gastrointestinal Effects: Monitor for diarrhea and abdominal discomfort; dose adjustment may be necessary if side effects are severe.
Interactions with Norlyroc
Common Drug Interactions
- Other Medications: Patients should inform their healthcare provider about all medications they are taking, particularly other opioid medications, as well as medications that may affect gastrointestinal motility.
Alternatives to Norlyroc
- Other Treatments for OIC: Alternatives may include other laxatives or opioid antagonists (such as methylnaltrexone), depending on the specific needs of the patient.
