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Nitro-Bid

Nitro-Bid (generic name: nitroglycerin) is a medication used primarily for the treatment of angina pectoris (chest pain) caused by coronary artery disease. It belongs to a class of drugs known as nitrates, which help to dilate blood vessels, improve blood flow to the heart, and reduce the heart's workload.



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Frequently Asked Questions

How quickly does Nitro-Bid work?
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Nitro-Bid ointment usually takes about 20 to 30 minutes to start working, and its effects can last several hours.

Can I take Nitro-Bid with food?
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Yes, Nitro-Bid can be used with or without food.

What should I do if I miss a dose?
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If you miss a dose of the ointment, apply it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule.

Are there any dietary restrictions while using Nitro-Bid?
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There are no specific dietary restrictions while using Nitro-Bid.

Is Nitro-Bid safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Nitro-Bid during these periods.

Comprehensive Drug Guide

How Does Nitro-Bid Work?

Nitroglycerin works by releasing nitric oxide, which relaxes and dilates blood vessels (veins and arteries). This vasodilation reduces the amount of blood returning to the heart (preload) and decreases the heart's oxygen demand, alleviating angina symptoms.

Common Dosages

  • Ointment: usually 2% nitroglycerin.
  • Transdermal Patch: various strengths.

Typical Dosing

  • For angina, the ointment is typically applied to the skin in a specific dose, often starting at 0.5 inches to 2 inches of ointment, applied to a hairless area of the skin. The dosing may be adjusted based on individual response.
  • The transdermal patch is usually applied once daily and worn for 12 to 14 hours before being removed.


Typical Dosing

FDA Approved Indications

  • Angina Pectoris: for the prevention and treatment of angina attacks.
  • Heart Failure: in some cases, to improve symptoms.


Who Shouldn't Take Nitro-Bid?

  • Known hypersensitivity to nitroglycerin or any component of the formulation.
  • Severe anemia.
  • Increased intracranial pressure or head trauma.
  • Use of phosphodiesterase inhibitors (e.g., sildenafil) within 24 to 48 hours.


Advice From The Pharmacist

  • Apply Nitro-Bid ointment to a clean, dry area of skin and avoid rubbing it in. Rotate application sites to minimize skin irritation.
  • Store the medication in its original container, away from moisture and heat.
  • Monitor for any signs of dizziness or headache, which are common side effects.


Side Effects of Nitro-Bid

Common Side Effects

  • Headache
  • Dizziness or lightheadedness
  • Flushing
  • Nausea
  • Skin irritation at the application site


Uncommon/Severe Side Effects

  • Severe hypotension (low blood pressure)
  • Syncope (fainting)
  • Allergic reactions (rash, itching, swelling).


Risks and Warnings of Nitro-Bid

  • Blood Pressure Monitoring: Monitor blood pressure regularly, especially after initiating treatment or adjusting dosage.
  • Avoid Abrupt Discontinuation: Gradual withdrawal is recommended to prevent rebound angina.


Interactions with Nitro-Bid

Common Drug Interactions

  • Phosphodiesterase Inhibitors: Concurrent use with these medications can lead to severe hypotension.
  • Antihypertensive Agents: May have additive effects, leading to increased risk of low blood pressure.


Alternatives to Nitro-Bid

  • Other Antianginal Agents: Such as beta-blockers or calcium channel blockers for managing angina.
  • Long-Acting Nitrates: Other formulations of nitroglycerin for chronic management of angina.