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Niacin ER (Antihyperlipidemic)

Niacin ER (extended-release niacin) is a formulation of niacin, also known as vitamin B3, used primarily to manage cholesterol levels and reduce the risk of cardiovascular disease. It is effective in increasing high-density lipoprotein (HDL) cholesterol and lowering low-density lipoprotein (LDL) cholesterol and triglycerides. Niacin ER is particularly beneficial for patients who need an extended-release option to minimize gastrointestinal side effects.



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Frequently Asked Questions

How quickly does Niacin ER work?
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Patients may begin to see improvements in cholesterol levels within 4 to 12 weeks of starting treatment.

Can I take Niacin ER with food?
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Yes, it is recommended to take Niacin ER with food to minimize gastrointestinal side effects.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while using Niacin ER?
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There are no specific dietary restrictions while using Niacin ER, but maintaining a heart-healthy diet is encouraged.

Is Niacin ER safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Niacin ER during these periods.

Comprehensive Drug Guide

How Does Niacin ER (Antihyperlipidemic) Work?

Niacin ER works by inhibiting the release of free fatty acids from adipose tissue, which decreases hepatic production of triglycerides. This reduction leads to lower levels of LDL cholesterol and triglycerides while simultaneously increasing HDL cholesterol, which helps to remove cholesterol from the bloodstream.



Common Dosages

  • Extended-Release Tablets: Common strengths include 500 mg, 750 mg, and 1000 mg.

Typical Dosing

  • The usual starting dose for managing cholesterol levels is 500 mg taken orally once daily, which may be gradually increased based on individual response and tolerability, with a maximum dose typically not exceeding 2000 mg per day.


Typical Dosing

FDA Approved Indications

  • Hyperlipidemia: as an adjunct to diet and exercise for the treatment of patients with elevated cholesterol levels.
  • Pellagra: for the treatment of niacin deficiency.


Who Shouldn't Take Niacin ER (Antihyperlipidemic)?

  • Known hypersensitivity to niacin or any component of the formulation.
  • Active liver disease or significant liver impairment.
  • Severe peptic ulcer disease.


Advice From The Pharmacist

  • Take Niacin ER with food to minimize gastrointestinal side effects and improve absorption.
  • Monitor cholesterol levels regularly to assess treatment effectiveness.
  • Report any unusual symptoms, especially those related to liver function or flushing, to your healthcare provider.


Side Effects of Niacin ER (Antihyperlipidemic)

Common Side Effects

  • Flushing or warmth of the skin
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain


Uncommon/Severe Side Effects

  • Liver toxicity (elevated liver enzymes)
  • Severe allergic reactions (rash, itching, swelling).


Risks and Warnings of Niacin ER (Antihyperlipidemic)

  • Liver Function: Regular monitoring of liver function tests is recommended, especially at higher doses.
  • Flushing: Flushing is a common side effect; consider taking an aspirin 30 minutes before the dose to help mitigate this reaction.


Interactions with Niacin ER (Antihyperlipidemic)

Common Drug Interactions

  • Other Cholesterol-Lowering Medications: Caution is advised when used in conjunction with statins or other lipid-lowering agents, as there may be an increased risk of liver toxicity.
  • Blood Pressure Medications: Monitor blood pressure regularly, as niacin can cause hypotension in some individuals.


Alternatives to Niacin ER (Antihyperlipidemic)

  • Other Lipid-Lowering Agents: Such as statins or fibrates for managing cholesterol levels.
  • Lifestyle Modifications: Dietary changes and increased physical activity to improve cholesterol levels.