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Nextstellis

Nextstellis is a combination oral contraceptive that contains estetrol and drospirenone. It is used for the prevention of pregnancy and is notable for its unique estrogen component, estetrol, which is a natural estrogen derived from plants. Nextstellis offers an alternative to traditional hormonal contraceptives, aiming to provide effective contraception with potentially fewer side effects.



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Frequently Asked Questions

How quickly does Nextstellis work?
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Nextstellis is effective after 7 days of consistent use if you start taking it at least 7 days before having unprotected sex; otherwise, additional contraception is needed during that time.

Can I take Nextstellis with food?
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Yes, you can take Nextstellis with or without food, based on your preference.

What should I do if I miss a dose?
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If you miss a dose, follow the instructions provided with your medication. Typically, take the missed dose as soon as you remember, and if it's close to the time for your next dose, skip the missed dose.

Are there any dietary restrictions while using Nextstellis?
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There are no specific dietary restrictions, but maintaining a healthy lifestyle is advisable.

Is Nextstellis safe during pregnancy or breastfeeding?
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Nextstellis is not recommended during pregnancy; consult your healthcare provider if you are breastfeeding, as hormonal contraceptives can affect milk production.

Comprehensive Drug Guide

How Does Nextstellis Work?


  • Suppresses the release of eggs from the ovaries (ovulation).
  • Thickens cervical mucus to impede sperm movement.
  • Alters the endometrium (uterine lining) to reduce the likelihood of implantation.


What is Nextstellis Used For?


Common Dosages

  • Tablets: Each tablet contains 15 mg of estetrol and 3 mg of drospirenone.

Typical Dosing

  • The usual regimen involves taking one tablet daily at the same time for 28 consecutive days, with the pack containing 24 active tablets and 4 placebo tablets.


Typical Dosing

FDA Approved Indications

  • Contraception: for the prevention of pregnancy in females of reproductive age.


Who Shouldn't Take Nextstellis?

  • Known hypersensitivity to estetrol, drospirenone, or any component of the formulation.
  • A history of blood clots, stroke, or certain cardiovascular conditions.
  • Uncontrolled high blood pressure or severe liver disease.


Advice From The Pharmacist

  • Take Nextstellis exactly as prescribed, and try to take it at the same time each day to maintain effective levels.
  • If you miss a dose, follow the specific instructions provided with the medication, which may vary depending on how many doses are missed.
  • Monitor for any side effects and report significant issues to your healthcare provider.


Side Effects of Nextstellis

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Mood changes
  • Spotting or breakthrough bleeding


Uncommon/Severe Side Effects

  • Blood clots (symptoms include swelling, pain, and redness in the legs)
  • Liver problems (symptoms include jaundice)
  • Severe allergic reactions (rash, itching, swelling).


Risks and Warnings of Nextstellis

  • Cardiovascular Risks: There is an increased risk of thromboembolism; patients should be aware of the signs and symptoms.
  • Regular Check-ups: Routine follow-up appointments are advisable to monitor for any potential side effects or complications.


Interactions with Nextstellis

Common Drug Interactions

  • Other Hormonal Contraceptives: Use caution when combining with other hormonal contraceptives, as this can increase the risk of side effects.
  • Certain Medications: Some medications may reduce the effectiveness of Nextstellis, including certain antibiotics and medications used for seizures.


Alternatives to Nextstellis

  • Other Oral Contraceptives: Such as those containing different combinations of estrogen and progestin.
  • Non-Hormonal Contraceptives: Barrier methods like condoms or copper IUDs may be considered for patients who prefer not to use hormonal contraception.