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NexoBrid
NexoBrid is a topical enzymatic debridement agent used for the treatment of burns, specifically in patients with deep partial-thickness burns. It contains a mixture of proteolytic enzymes derived from the pineapple plant (bromelain), which helps remove necrotic tissue and promote healing without the need for surgical debridement.
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Frequently Asked Questions
How quickly does NexoBrid work?
NexoBrid typically facilitates the removal of necrotic tissue within a few days, allowing for better healing conditions.
Can I use NexoBrid with other medications?
Consult your healthcare provider before using NexoBrid with other topical treatments to avoid interactions.
What should I do if I miss a dose?
If you miss an application, apply it as soon as you remember, unless it's close to the time for the next scheduled application.
Are there any dietary restrictions while using NexoBrid?
There are no specific dietary restrictions while using NexoBrid.
Is NexoBrid safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using NexoBrid in these situations.
Comprehensive Drug Guide
How Does NexoBrid Work?
NexoBrid works by selectively breaking down proteins in necrotic (dead) tissue through the action of its enzymes. This process helps remove the damaged tissue while preserving viable tissue underneath, facilitating the healing process and preparing the area for further treatment.
Common Dosages
- Gel: 2.5 g per application.
Typical Dosing
- Apply NexoBrid to the affected area once daily, covering the burn with a thick layer of the gel. The application may need to be left on for up to 4 hours, after which it should be rinsed off.
Typical Dosing
FDA Approved Indications
- Debridement of Burn Wounds: specifically for the removal of eschar in patients with deep partial-thickness burns.
Who Shouldn't Take NexoBrid?
- Known hypersensitivity to bromelain or any component of the formulation.
- Burns that are greater than 10% of the total body surface area (TBSA).
- Infected wounds or wounds with signs of infection.
Advice From The Pharmacist
- Follow the application instructions carefully, and ensure that the affected area is cleaned before applying NexoBrid.
- Monitor for signs of allergic reactions or worsening of the burn area; if these occur, contact your healthcare provider immediately.
- Avoid contact with eyes and mucous membranes; if contact occurs, rinse thoroughly with water.
Side Effects of NexoBrid
Common Side Effects
- Skin irritation
- Burning sensation at the application site
- Redness or erythema
- Itching
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Signs of infection (increased pain, swelling, or discharge).
Risks and Warnings of NexoBrid
- Wound Infection: Close monitoring of the treated area is necessary to prevent and identify any signs of infection.
- Not for Use on Infected Wounds: Ensure that the burn is not infected prior to treatment with NexoBrid.
Interactions with NexoBrid
Common Drug Interactions
- Other Topical Agents: Use caution when applying other topical medications to the same area to avoid irritation.
Alternatives to NexoBrid
- Surgical Debridement: May be necessary for some burn cases.
- Other Topical Agents: Such as silver sulfadiazine for burn treatment.
