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Nexlizet
Nexlizet is a combination medication that contains bempedoic acid and ezetimibe. It is primarily used to help lower cholesterol levels in adults with primary hyperlipidemia (high cholesterol) or mixed dyslipidemia, particularly in those who require additional lipid-lowering therapy beyond statins.
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Frequently Asked Questions
How quickly does Nexlizet work?
Patients may begin to see changes in their cholesterol levels within a few weeks, but optimal results may take several weeks to months.
Can I take Nexlizet with food?
Yes, Nexlizet can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule.
Is Nexlizet safe during pregnancy?
Nexlizet should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for signs of severe allergic reactions or symptoms of liver problems, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Nexlizet Work?
Bempedoic acid works by inhibiting ATP citrate lyase, an enzyme involved in the cholesterol synthesis pathway in the liver. Ezetimibe, on the other hand, reduces cholesterol absorption from the diet in the intestines. The combination of these two mechanisms helps lower total cholesterol, LDL cholesterol, and triglycerides.
Common Dosages
- Tablets: Commonly prescribed strength is 180 mg of bempedoic acid and 10 mg of ezetimibe.
Typical Dosing
- Adults: The usual recommended dose is one tablet taken orally once daily, with or without food.
Typical Dosing
FDA Approved Indications
- Adjunctive therapy to diet and exercise to reduce elevated LDL cholesterol in adults with primary hyperlipidemia or mixed dyslipidemia.
Who Shouldn't Take Nexlizet?
- Known hypersensitivity to bempedoic acid, ezetimibe, or any component of the formulation.
- Active liver disease or unexplained persistent elevations of liver transaminases.
Advice From The Pharmacist
- Take Nexlizet exactly as prescribed, and do not exceed the recommended dose.
- Monitor your cholesterol levels as directed by your healthcare provider to evaluate the effectiveness of the medication.
- Maintain a healthy diet and lifestyle to support cholesterol management.
Side Effects of Nexlizet
Common Side Effects
- Muscle pain or weakness
- Abdominal pain
- Diarrhea
- Elevated liver enzymes
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Liver problems (symptoms may include jaundice, dark urine, or severe fatigue)
Risks and Warnings of Nexlizet
- Liver Monitoring: Regular monitoring of liver function tests is recommended, especially in patients with a history of liver disease.
- Myopathy Risk: Caution is advised in patients with a history of muscle disorders or those taking other cholesterol-lowering medications, as there may be an increased risk of muscle-related side effects.
Interactions with Nexlizet
Common Drug Interactions
- Other Lipid-Lowering Agents: Inform your healthcare provider about all medications you are taking, especially other lipid-lowering therapies, to avoid potential interactions.
- Warfarin: Monitor INR levels closely if taking Nexlizet with warfarin, as there may be an interaction affecting anticoagulation.
Alternatives to Nexlizet
- Statins: Such as atorvastatin or rosuvastatin for managing high cholesterol.
- Other Non-Statin Therapies: Such as PCSK9 inhibitors or fibrates for additional cholesterol management.
