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Nexiclon XR
Nexiclon XR (generic name: clonidine extended-release) is a medication primarily used for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents aged 6 to 17 years. It may also be used in adults for hypertension management. Clonidine is an alpha-2 adrenergic agonist that works by affecting certain receptors in the brain to help improve attention, focus, and impulse control.
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Frequently Asked Questions
How quickly does Nexiclon XR work for ADHD?
Patients may begin to notice improvements in attention and behavior within 1 to 2 weeks of starting treatment.
Can I take Nexiclon XR with food?
Yes, Nexiclon XR can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Nexiclon XR?
There are no specific dietary restrictions while using Nexiclon XR.
Is Nexiclon XR safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Nexiclon XR during these periods.
Comprehensive Drug Guide
How Does Nexiclon XR Work?
Clonidine works by stimulating alpha-2 adrenergic receptors in the brain, which reduces the release of norepinephrine. This action decreases sympathetic outflow, leading to a reduction in blood pressure and improved regulation of attention and behavior in patients with ADHD.
What is Nexiclon XR Used For?
Common Dosages
- Extended-Release Tablets: Common strengths include 0.1 mg, 0.2 mg, and 0.3 mg.
Typical Dosing
- For ADHD, the usual starting dose is 0.1 mg once daily, which may be adjusted based on response, with a maximum dose typically not exceeding 0.4 mg per day.
Typical Dosing
FDA Approved Indications
- ADHD: for the treatment of attention deficit hyperactivity disorder in pediatric patients.
- Hypertension: as part of a comprehensive treatment plan.
Off-Label Uses
Pediatric Dosing
Who Shouldn't Take Nexiclon XR?
- Known hypersensitivity to clonidine or any component of the formulation.
- Severe bradycardia (slow heart rate).
- Severe coronary insufficiency or other significant cardiac disorders.
Advice From The Pharmacist
- Take Nexiclon XR exactly as prescribed, and do not stop taking it abruptly; tapering may be required to prevent withdrawal symptoms.
- Monitor blood pressure regularly to assess the effectiveness of the treatment and adjust dosage as needed.
- Report any signs of sedation, dizziness, or severe side effects to your healthcare provider.
Side Effects of Nexiclon XR
Common Side Effects
- Drowsiness or sedation
- Dry mouth
- Fatigue
- Constipation
- Hypotension (low blood pressure)
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Bradycardia (slow heart rate)
Risks and Warnings of Nexiclon XR
- Caution in Cardiac Conditions: Use with caution in patients with a history of heart disease, as clonidine can affect heart rate and blood pressure.
- Sedation Risk: Monitor for excessive sedation, especially in children; dosage adjustments may be necessary.
Interactions with Nexiclon XR
Common Drug Interactions
- CNS Depressants: Use caution when combining with other central nervous system depressants, such as alcohol or benzodiazepines, as this may enhance sedative effects.
- Antihypertensive Agents: Be aware of potential additive effects on blood pressure when used with other antihypertensive medications.
Alternatives to Nexiclon XR
- Other ADHD Medications: Such as stimulants (e.g., methylphenidate, amphetamines) or non-stimulant options (e.g., atomoxetine) for managing ADHD symptoms.
- Other Antihypertensives: Depending on individual patient needs and medical history.
