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Nebivolol HCl
Nebivolol HCl is a beta-1 adrenergic blocker used primarily to treat hypertension (high blood pressure). It is known for its selective action on beta-1 receptors and additional vasodilatory effects, which help lower blood pressure while minimizing side effects compared to non-selective beta-blockers.
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Frequently Asked Questions
How quickly does nebivolol HCl work?
Patients may start to see effects on blood pressure within 1 to 2 weeks, but optimal control may take longer.
Can I take nebivolol HCl with food?
Yes, nebivolol can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using nebivolol HCl?
There are no specific dietary restrictions while using nebivolol, but maintaining a balanced diet is advisable for overall health.
Is nebivolol HCl safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using nebivolol, as its safety during these periods is not fully established.
Comprehensive Drug Guide
How Does Nebivolol HCl Work?
Nebivolol works by selectively blocking beta-1 adrenergic receptors in the heart, leading to a decrease in heart rate and myocardial contractility. Additionally, it promotes the release of nitric oxide, resulting in vasodilation and further lowering of blood pressure.
Common Dosages
- Tablets: 2.5 mg, 5 mg, 10 mg, and 20 mg.
Typical Dosing
- The usual starting dose for adults is 5 mg taken orally once daily, which may be adjusted based on blood pressure response, with a maximum recommended dose of 40 mg per day.
Typical Dosing
FDA Approved Indications
- Hypertension: for the treatment of high blood pressure, either alone or in combination with other antihypertensive agents.
Who Shouldn't Take Nebivolol HCl?
- Known hypersensitivity to nebivolol or any component of the formulation.
- Severe bradycardia (slow heart rate).
- Heart block greater than first degree or severe asthma.
Advice From The Pharmacist
- Take nebivolol exactly as prescribed, and do not stop taking it suddenly without consulting your healthcare provider, as this may cause rebound hypertension.
- Monitor your blood pressure regularly, and report any significant changes or symptoms such as dizziness or fainting.
- Be cautious when engaging in activities that require mental alertness, as nebivolol may cause fatigue or dizziness.
Side Effects of Nebivolol HCl
Common Side Effects
- Fatigue
- Dizziness
- Nausea
- Headache
- Diarrhea
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Bradycardia
- Respiratory difficulties, especially in patients with asthma.
Risks and Warnings of Nebivolol HCl
- Bradycardia: Monitor heart rate; dose adjustments may be necessary if bradycardia occurs.
- Respiratory Issues: Use with caution in patients with asthma or other respiratory conditions due to potential bronchoconstriction from beta-blockers.
- Diabetes: Beta-blockers may mask symptoms of hypoglycemia; caution is advised in diabetic patients.
Interactions with Nebivolol HCl
Common Drug Interactions
- CNS Depressants: Use caution when combining with other CNS depressants, as they may increase sedation.
- Other Antihypertensives: Monitor blood pressure closely if used in combination with other antihypertensive agents.
Alternatives to Nebivolol HCl
- Other Beta-Blockers: Such as metoprolol or atenolol for similar indications.
- Calcium Channel Blockers: For patients who cannot tolerate beta-blockers.
