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Nayzilam
Nayzilam (midazolam) is a benzodiazepine medication used for the intranasal treatment of seizure clusters in patients with epilepsy. It acts as a rapid-onset sedative and anticonvulsant, providing quick relief from acute seizures.
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Frequently Asked Questions
How quickly does Nayzilam work?
Nayzilam typically begins to work within 10 minutes after administration, providing rapid relief from seizures.
Can I use Nayzilam with other seizure medications?
Yes, but consult your healthcare provider to ensure safe and effective use alongside other medications.
What should I do if I miss a dose?
Nayzilam is used as needed for seizure clusters; if you miss a dose, use it as soon as you recognize a seizure cluster.
Is Nayzilam safe during pregnancy?
Consult your healthcare provider before using Nayzilam during pregnancy to evaluate potential risks and benefits.
What are the signs of serious side effects to watch for?
Monitor for signs of respiratory depression or severe allergic reactions, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Nayzilam Work?
Nayzilam works by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This action leads to increased inhibitory neurotransmission in the brain, resulting in sedation, muscle relaxation, and anticonvulsant effects.
Common Dosages
- Intranasal spray: Each spray delivers 5 mg of midazolam.
Typical Dosing
- Adults and Children (12 years and older): The usual recommended dose is 5 mg administered into one nostril. If seizures do not stop after 10 minutes, a second dose may be administered, but the total dose should not exceed 10 mg in 24 hours.
Typical Dosing
FDA Approved Indications
- The treatment of seizure clusters in patients with epilepsy.
Who Shouldn't Take Nayzilam?
- Known hypersensitivity to midazolam or any component of the formulation.
- Acute narrow-angle glaucoma.
Advice From The Pharmacist
- Administer Nayzilam as soon as a seizure cluster is recognized, and follow the prescribed dosing regimen.
- Avoid alcohol and other central nervous system depressants while using Nayzilam, as these can increase sedation.
- Keep track of seizure frequency and report any changes to your healthcare provider.
Side Effects of Nayzilam
Common Side Effects
- Drowsiness
- Dizziness
- Nasal discomfort
- Fatigue
Uncommon/Severe Side Effects
- Respiratory depression
- Severe allergic reactions (rash, itching, swelling)
Risks and Warnings of Nayzilam
- Dependence and Withdrawal: Long-term use of benzodiazepines can lead to dependence; tapering may be necessary to avoid withdrawal symptoms.
- Respiratory Effects: Use with caution in patients with respiratory issues, as it can depress respiration.
Interactions with Nayzilam
Common Drug Interactions
- Other CNS Depressants: Use caution when combining with other medications that cause sedation, such as opioids, alcohol, or other benzodiazepines.
- Anticonvulsants: Monitor closely when used in combination with other antiepileptic drugs.
Alternatives to Nayzilam
- Other Benzodiazepines: Such as lorazepam or diazepam for acute seizure management.
- Rescue Medications: Other non-benzodiazepine options for seizure clusters may also be considered.
