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Naltrex
Namenda (memantine) is a non-competitive NMDA receptor antagonist used primarily for the treatment of moderate to severe Alzheimer's disease. It works by regulating the activity of glutamate, a neurotransmitter involved in learning and memory, helping to improve cognitive function and slow the progression of symptoms.
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Comprehensive Drug Guide
How Does Naltrex Work?
Namenda works by selectively blocking the NMDA receptors in the brain, which helps to prevent excessive stimulation by glutamate. By modulating glutamate activity, Namenda may protect brain cells from damage and improve symptoms associated with Alzheimer's disease.
Common Dosages
- Tablets: 5 mg and 10 mg.
- Oral solution: 10 mg/mL.
Typical Dosing
- Adults: The usual starting dose is 5 mg once daily, which may be increased to a target dose of 10 mg twice daily after one week. The maximum recommended dose is 20 mg per day.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe Alzheimer's disease in adults.
Who Shouldn't Take Naltrex?
- Known hypersensitivity to memantine or any component of the formulation
Advice From The Pharmacist
- Take Namenda exactly as prescribed, and do not exceed the recommended dose.
- Consistency in timing is important; take it at the same time each day to maintain steady levels in the body.
- Inform your healthcare provider about all medications you are taking, as some may interact with Namenda.
Side Effects of Naltrex
Common Side Effects
- Dizziness
- Headache
- Confusion
- Constipation
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Changes in heart rate or rhythm
Risks and Warnings of Naltrex
- Cognitive Effects: Monitor for any worsening cognitive function or unusual changes in behavior and report them to your healthcare provider.
- Renal Function: Use with caution in patients with renal impairment, as dosage adjustments may be necessary.
Interactions with Naltrex
Common Drug Interactions
- Other NMDA Antagonists: Caution is advised when used in combination with other medications that affect glutamate signaling.
- Medications that Affect Renal Function: Be aware of potential interactions with drugs that may impact kidney function.
Alternatives to Naltrex
- Other Alzheimer's Treatments: Such as cholinesterase inhibitors (e.g., donepezil, rivastigmine) for managing cognitive symptoms.
- Supportive Therapies: Behavioral therapies and lifestyle changes to support cognitive function and quality of life.
