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Mytesi
Mytesi, the brand name for crofelemer, is an anti-diarrheal medication specifically used to manage non-infectious diarrhea in patients with HIV/AIDS who are receiving antiretroviral therapy (ART). It works by regulating fluid secretion in the intestines, helping to reduce diarrhea without affecting the body's immune response or interfering with HIV treatments. Mytesi is not used for infectious causes of diarrhea and is part of a long-term management plan for people with HIV/AIDS experiencing diarrhea due to their medications.
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Frequently Asked Questions
How long does it take for Mytesi to start working?
Many patients experience a reduction in diarrhea symptoms within a few days to a week after starting Mytesi, but it may take longer for some individuals. It is important to continue taking the medication as prescribed for optimal results.
How long does it take for Mytesi to start working?
Many patients experience a reduction in diarrhea symptoms within a few days to a week after starting Mytesi, but it may take longer for some individuals. It is important to continue taking the medication as prescribed for optimal results.
Can Mytesi be used for diarrhea caused by infections?
No, Mytesi is indicated only for non-infectious diarrhea associated with HIV treatment. If your diarrhea is due to an infection, other treatments are needed.
What should I do if I miss a dose of Mytesi?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Can I take Mytesi with my HIV medications?
Yes, Mytesi is specifically designed to be used alongside antiretroviral therapy and does not interfere with the efficacy of HIV medications.
Is Mytesi safe for long-term use?
Yes, Mytesi is considered safe for long-term use in managing chronic non-infectious diarrhea in people with HIV. Regular follow-ups with your healthcare provider will ensure it continues to be effective and safe for your condition.
Comprehensive Drug Guide
How Does Mytesi Work?
Mytesi works by inhibiting two chloride channels, the cystic fibrosis transmembrane conductance regulator (CFTR) and the calcium-activated chloride channel (CaCC), which regulate fluid and electrolyte secretion in the intestines. By blocking these channels, Mytesi reduces the amount of water and electrolytes secreted into the gut, which decreases diarrhea without affecting gastrointestinal motility or the absorption of other medications.
Common Dosages
- 125 mg delayed-release tablets
Typical Dosing
- The typical dose of Mytesi is 125 mg (one tablet) twice daily, taken by mouth.
- Tablets should be swallowed whole and not crushed or chewed. They can be taken with or without food.
Typical Dosing
FDA Approved Indications
- Symptomatic relief of non-infectious diarrhea in adults with HIV/AIDS who are receiving antiretroviral therapy (ART).
Who Shouldn't Take Mytesi?
- Known hypersensitivity to crofelemer or any of the ingredients in the formulation.
Advice From The Pharmacist
- Take Mytesi as prescribed, twice daily, with or without food. Ensure you take it consistently to manage diarrhea effectively.
- Do not crush or chew the tablets. Swallow them whole to ensure the proper release of the medication in the intestines.
- Continue taking your antiretroviral therapy (ART) as directed by your healthcare provider. Mytesi is designed to work alongside your HIV treatment without affecting its efficacy.
- If your diarrhea worsens or becomes accompanied by other symptoms such as fever, consult your healthcare provider to rule out an infectious cause.
- Stay hydrated to prevent dehydration, especially if diarrhea persists.
Side Effects of Mytesi
Common Side Effects
- Upper respiratory infections (common cold)
- Cough
- Flatulence
- Abdominal pain
Uncommon/Severe Side Effects
- Severe allergic reactions: Rash, itching, swelling of the face or throat, or difficulty breathing.
Risks and Warnings of Mytesi
- Infectious diarrhea: Mytesi is not indicated for the treatment of infectious diarrhea. Patients experiencing diarrhea due to bacterial, viral, or parasitic infections should consult their healthcare provider for appropriate treatment.
- Allergic reactions: Although rare, allergic reactions to Mytesi may occur. Patients should stop using the medication and seek immediate medical attention if they develop symptoms such as rash, swelling, or difficulty breathing.
Interactions with Mytesi
Common Drug Interactions
- Mytesi has a low risk of drug interactions and does not interfere with the absorption or efficacy of antiretroviral medications. However, always inform your healthcare provider about any other medications, supplements, or herbal products you are taking.
Alternatives to Mytesi
- Loperamide (Imodium): Another antidiarrheal medication that can be used for short-term relief of diarrhea, though it may not be as effective for chronic non-infectious diarrhea related to HIV treatment.
- Diphenoxylate/atropine (Lomotil): An antidiarrheal combination used for the management of diarrhea but may have more side effects, including drowsiness or constipation.
- Octreotide (Sandostatin): A medication used for severe cases of diarrhea, particularly in conditions like carcinoid syndrome, but is more invasive due to its injectable form.
