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Myorisan

Myorisan is the brand name for isotretinoin, a medication primarily prescribed for the treatment of severe recalcitrant nodular acne. It belongs to the retinoid class of drugs, which are derived from vitamin A. Myorisan works by reducing the amount of oil released by oil glands in the skin, helping the skin renew itself more quickly, which prevents severe acne breakouts. It is often used when other acne treatments, such as antibiotics or topical medications, have failed to provide effective results.

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Frequently Asked Questions

How long does it take for Myorisan to work?

Most patients begin to see significant improvements in their acne within the first two months of treatment, but full results may take longer. A typical course lasts 15 to 20 weeks.

Can I take Myorisan if I’m pregnant or planning to become pregnant?

No. Myorisan should never be taken during pregnancy due to the high risk of severe birth defects. Women of childbearing potential must use two forms of birth control and undergo regular pregnancy tests during treatment.

What should I do if I miss a dose of Myorisan?

If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

Can Myorisan cause permanent side effects?

Most side effects of Myorisan are temporary and resolve after discontinuation. However, in rare cases, some side effects such as changes in mood or liver damage can be more persistent.

Is Myorisan the same as Accutane?

Yes, Myorisan and Accutane contain the same active ingredient, isotretinoin. They are simply different brands of the same medication.

Comprehensive Drug Guide

How Does Myorisan Work?

Myorisan works by decreasing the size and activity of the skin’s oil glands (sebaceous glands), which reduces the production of oil (sebum). Excessive sebum is a primary cause of severe acne, as it clogs pores and promotes the growth of acne-causing bacteria. In addition to reducing oil production, Myorisan helps to decrease inflammation and encourages skin cell turnover, helping to prevent the formation of acne.

Common Dosages

Oral capsules: 10 mg, 20 mg, 30 mg, and 40 mg

Typical Dosing

The typical dosing for Myorisan is based on body weight, with the starting dose typically being 0.5 to 1 mg per kg per day. The total daily dose is divided into two doses taken with meals.
The duration of treatment generally lasts for 15 to 20 weeks, with adjustments based on the patient's response and tolerance to the medication.

Typical Dosing

FDA Approved Indications

Severe recalcitrant nodular acne in patients who have not responded to other treatments, such as oral antibiotics.

Who Shouldn't Take Myorisan?

Pregnancy or planning to become pregnant (due to the high risk of severe birth defects)
Hypersensitivity to isotretinoin or any component of the formulation
Vitamin A hypersensitivity (as isotretinoin is derived from vitamin A)

Advice From The Pharmacist

Myorisan should be taken with food to improve absorption and reduce the risk of side effects.
Women of childbearing potential must use two forms of birth control starting one month before, during, and one month after treatment with Myorisan due to the risk of birth defects.
Regular blood tests will be required to monitor liver function, cholesterol, and triglyceride levels while taking Myorisan.
Avoid vitamin A supplements while on Myorisan to prevent toxicity.
Use a moisturizer and lip balm regularly, as Myorisan can cause dry skin and lips.

Side Effects of Myorisan

Common Side Effects

Dry skin and lips (chapped lips)
Nosebleeds
Joint or muscle pain
Sensitivity to sunlight
Dry eyes

Uncommon/Severe Side Effects

Birth defects (if taken during pregnancy)
Severe mood changes, depression, or suicidal thoughts
Liver toxicity (elevated liver enzymes)
High cholesterol or triglycerides

Risks and Warnings of Myorisan

Pregnancy Risk: Myorisan is highly teratogenic, meaning it can cause severe birth defects if taken during pregnancy. Women must use two effective forms of birth control and undergo regular pregnancy tests during treatment.
Mental Health: Myorisan has been linked to mood changes, depression, and suicidal thoughts. Patients should be closely monitored for any changes in mood or behavior.
Liver and Lipid Monitoring: Myorisan can cause elevated liver enzymes and increased cholesterol or triglyceride levels, so regular blood tests are required during treatment.

Interactions with Myorisan

Common Drug Interactions

Vitamin A supplements: Should be avoided, as they may increase the risk of vitamin A toxicity.
Tetracycline antibiotics: When combined with Myorisan, these may increase the risk of intracranial hypertension (increased pressure in the brain).
Alcohol: Should be limited, as both alcohol and Myorisan can raise triglyceride levels, increasing the risk of pancreatitis.

Alternatives to Myorisan

Accutane (isotretinoin): Another brand of isotretinoin, used for the same conditions.
Oral antibiotics: Such as doxycycline or minocycline, often used to treat moderate to severe acne before isotretinoin is considered.
Topical retinoids: Such as tretinoin (Retin-A), used for milder forms of acne.
Spironolactone: A hormone blocker used off-label to treat acne in women.