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MS Contin

MS Contin is a brand name for morphine sulfate extended-release, a potent opioid analgesic used for the management of chronic pain severe enough to require continuous, around-the-clock treatment. It is designed for long-term pain relief in patients who have not responded adequately to other pain management options.



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Frequently Asked Questions

How quickly does MS Contin work?
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MS Contin typically starts to relieve pain within 30 minutes, with peak effects occurring around 1 to 2 hours after taking the medication.

Can I take MS Contin with food?
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Yes, it can be taken with or without food; however, consistency in how you take it is important for optimal absorption.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while using MS Contin?
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There are no specific dietary restrictions, but maintaining hydration and a balanced diet can help manage constipation.

Is MS Contin safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using MS Contin, as it may affect the fetus or be excreted in breast milk.

Comprehensive Drug Guide

How Does MS Contin Work?

MS Contin works by binding to mu-opioid receptors in the central nervous system (CNS), leading to a decrease in the perception of pain and an altered emotional response to pain. This results in significant analgesic (pain-relieving) effects.



Common Dosages

  • Extended-Release Tablets: 15 mg, 30 mg, 60 mg, 100 mg, and 200 mg.

Typical Dosing

  • The initial dose for opioid-naive patients typically starts at 15 mg to 30 mg every 8 to 12 hours, with adjustments made based on individual response and tolerance.


Typical Dosing

FDA Approved Indications

  • Management of Pain: for the treatment of moderate to severe pain requiring long-term opioid treatment.


Who Shouldn't Take MS Contin?

  • Known hypersensitivity to morphine or any component of the formulation.
  • Severe respiratory depression or asthma.
  • Paralytic ileus or gastrointestinal obstruction.


Advice From The Pharmacist

  • Take MS Contin exactly as prescribed; do not exceed the recommended dose to minimize the risk of respiratory depression and overdose.
  • Swallow the tablets whole; do not crush or chew them, as this can release the entire dose at once and increase the risk of overdose.
  • Monitor for signs of sedation, respiratory depression, and constipation, which are common side effects of opioid use.


Side Effects of MS Contin

Common Side Effects

  • Drowsiness
  • Dizziness
  • Nausea
  • Vomiting
  • Constipation


Uncommon/Severe Side Effects

  • Respiratory depression (slow or shallow breathing)
  • Severe allergic reactions (rash, itching, swelling)
  • Risk of dependence and withdrawal symptoms upon discontinuation.


Risks and Warnings of MS Contin

  • Respiratory Depression: Monitor patients closely, especially during initiation or dose adjustments; this is a major risk associated with opioid use.
  • Dependence and Withdrawal: Long-term use may lead to physical dependence; gradual tapering is recommended when discontinuing therapy.
  • Caution in Older Adults: Older patients may be more sensitive to the effects of opioids and may require careful monitoring.


Interactions with MS Contin

Common Drug Interactions

  • CNS Depressants: Use caution when combining with other CNS depressants (e.g., benzodiazepines, alcohol) due to increased risk of sedation and respiratory depression.
  • Medications Affecting Liver Enzymes: Drugs that influence liver enzymes may alter morphine metabolism and require dosage adjustments.


Alternatives to MS Contin

  • Other Opioid Analgesics: Such as hydromorphone or oxycodone for pain management.
  • Non-Opioid Analgesics: Such as acetaminophen or NSAIDs for milder pain relief.