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Morphine Sulfate (PF)

Morphine sulfate (PF) is an opioid analgesic used to manage moderate to severe pain. It is particularly effective for pain associated with conditions such as cancer, post-operative pain, and severe injury. PF stands for "preservative-free," indicating that the formulation does not contain preservatives, making it suitable for certain patient populations.



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Frequently Asked Questions

How quickly does morphine sulfate work?
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Morphine sulfate typically starts to relieve pain within 30 minutes after administration, with peak effects usually occurring around 1 to 2 hours after taking it.

Can I take morphine sulfate with food?
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Yes, it can be taken with or without food, but taking it with food may help reduce gastrointestinal discomfort.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while using morphine sulfate?
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There are no specific dietary restrictions, but maintaining hydration and a balanced diet can help manage constipation.

Is morphine sulfate safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using morphine sulfate, as it may affect the fetus or be excreted in breast milk.

Comprehensive Drug Guide

How Does Morphine Sulfate (PF) Work?

Morphine sulfate works by binding to opioid receptors in the brain and spinal cord, primarily mu-opioid receptors. This action alters the perception of pain and emotional response to pain, leading to analgesia (pain relief) and sedation.



Common Dosages

  • Oral Tablets: 15 mg, 30 mg, 60 mg, and 100 mg.
  • Injectable Solutions: 1 mg/mL, 2 mg/mL, 5 mg/mL, and others.

Typical Dosing

  • For pain management, the initial oral dose for adults may range from 15 mg to 30 mg every 4 hours as needed, with adjustments based on individual response. For injectable forms, dosing will depend on the severity of pain and the route of administration.


Typical Dosing

FDA Approved Indications

  • Management of Pain: for moderate to severe pain in various clinical settings, including post-surgical and chronic pain.


Who Shouldn't Take Morphine Sulfate (PF)?

  • Known hypersensitivity to morphine or any component of the formulation.
  • Severe respiratory depression or asthma.
  • Paralytic ileus or gastrointestinal obstruction.


Advice From The Pharmacist

  • Take morphine sulfate exactly as prescribed, and do not exceed the recommended dose to minimize the risk of respiratory depression and overdose.
  • Monitor for signs of sedation, respiratory depression, and constipation, which are common side effects of opioid use.
  • Avoid alcohol and other CNS depressants while taking morphine, as they can enhance sedative effects.


Side Effects of Morphine Sulfate (PF)

Common Side Effects

  • Drowsiness
  • Dizziness
  • Nausea
  • Constipation
  • Dry mouth


Uncommon/Severe Side Effects

  • Respiratory depression (slow or shallow breathing)
  • Severe allergic reactions (rash, itching, swelling)
  • Risk of dependence and withdrawal symptoms upon discontinuation.


Risks and Warnings of Morphine Sulfate (PF)

  • Respiratory Depression: Monitor patients closely, especially during initiation or dose adjustments; this is a major risk associated with opioid use.
  • Dependence and Withdrawal: Long-term use may lead to physical dependence; gradual tapering is recommended when discontinuing therapy.
  • Caution in Older Adults: Older patients may be more sensitive to the effects of opioids and may require careful monitoring.


Interactions with Morphine Sulfate (PF)

Common Drug Interactions

  • CNS Depressants: Use caution when combining with other CNS depressants (e.g., benzodiazepines, alcohol) due to increased risk of sedation and respiratory depression.
  • Medications Affecting Liver Enzymes: Drugs that influence liver enzymes may alter morphine metabolism and require dosage adjustments.


Alternatives to Morphine Sulfate (PF)

  • Other Opioid Analgesics: Such as hydromorphone or oxycodone for pain management.
  • Non-Opioid Analgesics: Such as acetaminophen or NSAIDs may be suitable for mild to moderate pain.