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Minocycline HCl ER (Biphasic)

Minocycline HCl ER (extended-release) biphasic formulation is an antibiotic used primarily for the treatment of acne and various bacterial infections. This formulation allows for a gradual release of minocycline over an extended period, improving its efficacy and reducing the frequency of dosing.



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Frequently Asked Questions

How quickly does minocycline work?
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Patients may begin to notice improvements in their symptoms within a few days, but full effects for acne treatment can take several weeks.

Can I take minocycline with food?
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Minocycline can be taken with food, but avoid dairy products and antacids around the time of dosing to ensure optimal absorption.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule.

Is minocycline safe during pregnancy?
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Minocycline is generally not recommended during pregnancy. Consult your healthcare provider for alternatives.

What are the signs of serious side effects to watch for?
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Monitor for signs of severe allergic reactions, liver problems, or persistent headache, and seek immediate medical attention if these occur.

Comprehensive Drug Guide

How Does Minocycline HCl ER (Biphasic) Work?

Minocycline works by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit. This action effectively stops the growth of bacteria, making it useful in treating infections and reducing inflammation associated with acne.



Common Dosages

  • Extended-release capsules: Common strengths include 135 mg.

Typical Dosing

  • Adults and Adolescents: The usual recommended starting dose for acne treatment is 200 mg on the first day, followed by 100 mg once daily. Dosages for other infections may vary based on the specific infection and patient condition.


Typical Dosing

FDA Approved Indications

  • Treatment of acne vulgaris.
  • Treatment of various bacterial infections.


Who Shouldn't Take Minocycline HCl ER (Biphasic)?

  • Known hypersensitivity to minocycline or any component of the formulation.
  • Pregnancy or breastfeeding, due to potential effects on fetal development and nursing infants.
  • Children under 8 years of age, as it can cause tooth discoloration and affect bone development.


Advice From The Pharmacist

  • Take minocycline exactly as prescribed, and complete the full course of therapy, even if symptoms improve before finishing.
  • Avoid taking it with dairy products, antacids, or iron supplements, as these can reduce absorption.
  • Monitor for signs of gastrointestinal disturbances or allergic reactions and report these to your healthcare provider.


Side Effects of Minocycline HCl ER (Biphasic)

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Skin rash


Uncommon/Severe Side Effects

  • Severe allergic reactions (anaphylaxis)
  • Hepatotoxicity
  • Intracranial hypertension


Risks and Warnings of Minocycline HCl ER (Biphasic)

  • Photosensitivity: Minocycline can increase sensitivity to sunlight; patients should take precautions to avoid excessive sun exposure.
  • Superinfection: Prolonged use may lead to the overgrowth of non-susceptible organisms, including fungi.


Interactions with Minocycline HCl ER (Biphasic)

Common Drug Interactions

  • Antacids and Supplements: Avoid taking minocycline with antacids, iron supplements, or calcium-rich foods, as these can reduce absorption.
  • Other Antibiotics: Use caution when combining with other antibiotics to avoid potential antagonistic effects.


Alternatives to Minocycline HCl ER (Biphasic)

  • Other Tetracyclines: Such as doxycycline for similar indications.
  • Other Antibiotic Classes: Depending on the specific infection, alternatives may include penicillins or macrolides.