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Methylergonovine Maleate
Methylergonovine maleate is an ergot alkaloid used primarily to prevent and treat postpartum hemorrhage due to uterine atony. It works by stimulating uterine contractions, which helps to reduce bleeding after childbirth.
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Frequently Asked Questions
How quickly does methylergonovine maleate work?
Methylergonovine typically begins to work rapidly, with effects on uterine contractions observed within minutes of administration.
Can I take methylergonovine maleate with food?
Oral doses can be taken with or without food, but the injectable form is usually given in a hospital setting.
What should I do if I miss a dose?
If a dose is missed, it should be given as soon as possible, unless it is close to the time of the next dose. In that case, skip the missed dose and continue with the regular schedule.
Are there any dietary restrictions while using methylergonovine maleate?
There are no specific dietary restrictions, but it's important to follow the healthcare provider's instructions regarding monitoring and follow-up.
Is methylergonovine maleate safe during pregnancy or breastfeeding?
It is typically used postpartum and should be discussed with your healthcare provider regarding use while breastfeeding, as small amounts may be excreted in breast milk.
Comprehensive Drug Guide
How Does Methylergonovine Maleate Work?
Methylergonovine acts as an agonist at serotonin and alpha-adrenergic receptors in the smooth muscle of the uterus. This action increases the frequency and intensity of uterine contractions, leading to reduced uterine bleeding by promoting uterine tone.
Common Dosages
- Injectable Solution: 0.2 mg/mL.
- Tablets: 0.2 mg.
Typical Dosing
- For postpartum hemorrhage, the typical dosage is 0.2 mg given intramuscularly (IM) or 0.2 mg orally every 2 to 4 hours as needed. The IM route is often preferred for rapid action.
Typical Dosing
FDA Approved Indications
- Prevention and Treatment of Postpartum Hemorrhage: specifically for uterine atony following childbirth.
Who Shouldn't Take Methylergonovine Maleate?
- Known hypersensitivity to methylergonovine or any component of the formulation.
- Severe hypertension or preeclampsia.
- Uterine infections or significant cardiovascular disease.
Advice From The Pharmacist
- Administer methylergonovine as prescribed, typically after delivery of the placenta.
- Monitor blood pressure regularly, as it can cause hypertension.
- Be aware of potential side effects, and report any unusual symptoms, especially signs of severe headache or chest pain.
Side Effects of Methylergonovine Maleate
Common Side Effects
- Nausea
- Vomiting
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Hypertension
- Uterine hypertonicity (excessive uterine contractions)
- Allergic reactions (rash, itching, difficulty breathing)
Risks and Warnings of Methylergonovine Maleate
- Cardiovascular Effects: Use with caution in patients with a history of hypertension or cardiovascular disease, as methylergonovine can raise blood pressure.
- Uterine Hypertonicity: Monitor uterine tone and contractions closely to prevent excessive stimulation.
Interactions with Methylergonovine Maleate
Common Drug Interactions
- Other Vasoconstrictors: Use caution when combining with other medications that can elevate blood pressure or cause vasoconstriction.
Alternatives to Methylergonovine Maleate
- Oxytocin: Often used as a first-line agent for the prevention and treatment of postpartum hemorrhage.
- Carbetocin: Another synthetic uterotonin that may be used in specific situations.
