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Meperidine HCl
Meperidine HCl, commonly known as Demerol, is a synthetic opioid analgesic used to treat moderate to severe pain. It is often used for short-term pain relief in surgical settings or for managing pain associated with certain medical conditions.
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Frequently Asked Questions
How quickly does meperidine HCl work?
Meperidine typically starts to relieve pain within 10 to 15 minutes after injection, with oral administration taking longer.
Can I take meperidine HCl with food?
Yes, it can be taken with or without food, but taking it with food may help reduce gastrointestinal discomfort.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using meperidine HCl?
There are no specific dietary restrictions, but maintaining adequate hydration is advisable.
Is meperidine HCl safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using meperidine, as it may affect both mother and baby.
Comprehensive Drug Guide
How Does Meperidine HCl Work?
Meperidine works by binding to opioid receptors in the brain and spinal cord, leading to a decrease in the perception of pain. It also alters the emotional response to pain, providing both analgesic and sedative effects.
Common Dosages
- Injectable Solution: 25 mg/mL, 50 mg/mL, and 100 mg/mL.
- Oral Tablets: 50 mg.
Typical Dosing
- The typical starting dose for adults is 50 mg to 150 mg administered every 3 to 4 hours as needed for pain. For injection, doses may be adjusted based on pain severity and individual response.
Typical Dosing
FDA Approved Indications
- Pain Management: used for the relief of moderate to severe pain, particularly in surgical or acute care settings.
Who Shouldn't Take Meperidine HCl?
- Known hypersensitivity to meperidine or any component of the formulation.
- Severe respiratory depression or asthma.
- A history of substance use disorder or dependence.
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of MAOI therapy.
Advice From The Pharmacist
- Take meperidine exactly as prescribed and avoid exceeding the recommended dosage.
- Monitor for signs of respiratory depression, especially during the initiation of therapy or dose adjustments.
- Avoid alcohol and other CNS depressants while taking meperidine, as they can enhance sedative effects.
Side Effects of Meperidine HCl
Common Side Effects
- Drowsiness
- Dizziness
- Nausea
- Vomiting
- Constipation
Uncommon/Severe Side Effects
- Respiratory depression (slow or shallow breathing)
- Severe allergic reactions (rash, itching, swelling)
- Risk of dependence or withdrawal symptoms upon discontinuation.
Risks and Warnings of Meperidine HCl
- Respiratory Depression: Monitor patients closely, especially those with pre-existing respiratory conditions.
- CNS Effects: Be aware of the potential for sedation and impairment; caution is advised when driving or operating machinery.
- Use in Older Adults: Older patients may be more sensitive to the effects of opioids, requiring careful monitoring and dosage adjustments.
Interactions with Meperidine HCl
Common Drug Interactions
- CNS Depressants: Use caution when combining with other CNS depressants (e.g., benzodiazepines, alcohol) due to increased risk of respiratory depression and sedation.
- MAOIs: Avoid concurrent use, as this combination can lead to severe side effects.
Alternatives to Meperidine HCl
- Other Opioids: Such as hydromorphone or oxycodone for similar pain management.
- Non-Opioid Analgesics: Such as acetaminophen or NSAIDs for milder pain relief.
