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Matzim LA
Matzim LA (metformin hydrochloride) is an extended-release formulation of metformin, primarily used to manage type 2 diabetes mellitus. It helps control blood sugar levels by improving insulin sensitivity and reducing hepatic glucose production. Matzim LA is designed to provide a steady release of the medication over time, allowing for once-daily dosing.
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Frequently Asked Questions
How quickly does Matzim LA work to lower blood sugar?
Patients may see improvements in blood glucose levels within a few days to weeks after starting the medication.
Can I take Matzim LA with other diabetes medications?
Yes, Matzim LA can be taken in combination with other diabetes medications, but consult your healthcare provider for specific recommendations.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while taking Matzim LA?
There are no specific dietary restrictions, but maintaining a balanced diet and monitoring carbohydrate intake is advisable.
Is Matzim LA safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Matzim LA.
Comprehensive Drug Guide
How Does Matzim LA Work?
- Decreasing hepatic glucose production, thereby reducing the amount of sugar released into the bloodstream.
- Increasing insulin sensitivity in muscle and fat tissues, facilitating better uptake of glucose from the blood.
- Slowing the absorption of glucose from the gastrointestinal tract.
Common Dosages
- Extended-release tablets: 500 mg, 750 mg, and 1000 mg.
Typical Dosing
- The usual starting dose is 500 mg once daily, taken with the evening meal.
- The dose may be gradually increased based on blood glucose levels, up to a maximum of 2000 mg per day.
Typical Dosing
FDA Approved Indications
- Management of Type 2 Diabetes Mellitus: as an adjunct to diet and exercise to improve glycemic control.
Who Shouldn't Take Matzim LA?
- Known hypersensitivity to metformin or any component of the formulation.
- Severe renal impairment (eGFR less than 30 mL/min).
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
Advice From The Pharmacist
- Take Matzim LA with food to reduce gastrointestinal side effects.
- Regularly monitor blood sugar levels to assess the effectiveness of the medication.
- Maintain a balanced diet and exercise regimen as advised by your healthcare provider.
- Stay well-hydrated and report any symptoms of lactic acidosis (e.g., unusual muscle pain, trouble breathing, abdominal discomfort).
Side Effects of Matzim LA
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Stomach pain
- Loss of appetite
Uncommon/Severe Side Effects
- Lactic acidosis (a rare but serious condition)
- Vitamin B12 deficiency with long-term use
Risks and Warnings of Matzim LA
- Lactic Acidosis: Risk factors include renal impairment, severe dehydration, and excessive alcohol intake. Symptoms should be monitored closely.
- Renal Function: Regular monitoring of kidney function is necessary, especially in patients over 65 or those with risk factors for renal impairment.
- Hypoglycemia: While metformin alone typically does not cause low blood sugar, it can occur when combined with other antidiabetic medications.
Interactions with Matzim LA
Common Drug Interactions
- Diuretics: Can affect renal function and increase the risk of lactic acidosis.
- Corticosteroids: May raise blood glucose levels and interfere with the effectiveness of metformin.
- Alcohol: Increases the risk of lactic acidosis and may affect blood glucose levels.
Alternatives to Matzim LA
- Other Antidiabetic Medications: Such as sulfonylureas, DPP-4 inhibitors, or GLP-1 receptor agonists for managing type 2 diabetes.
- Insulin Therapy: For patients with more severe or uncontrolled diabetes.
