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Maraviroc
Maraviroc is an antiretroviral medication used to treat HIV-1 infection in adults and children. It is a CCR5 antagonist, which means it works by blocking the CCR5 co-receptor on the surface of T-cells. This action prevents HIV from entering and infecting these immune cells, thereby reducing the viral load in the body.
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Frequently Asked Questions
How quickly does maraviroc start working?
Maraviroc can begin to reduce viral load within weeks, but the full effect may take longer depending on the combination therapy used.
Can I take maraviroc with food?
Maraviroc can be taken with or without food, but it’s advisable to maintain consistency in how you take it.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using maraviroc?
There are no specific dietary restrictions, but maintaining a balanced diet is advisable.
Is maraviroc safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using maraviroc.
Comprehensive Drug Guide
How Does Maraviroc Work?
Maraviroc specifically targets and blocks the CCR5 co-receptor, which is utilized by HIV-1 to enter host cells. By inhibiting this receptor, maraviroc prevents the virus from successfully attaching to and entering the T-cells, thus limiting the spread of HIV within the body.
What is Maraviroc Used For?
Common Dosages
- Tablets: 150 mg and 300 mg.
Typical Dosing
- The usual recommended dose is 300 mg twice daily, although dosage may vary based on concomitant medications and individual patient factors. For patients with renal impairment, the dose may need to be adjusted.
Typical Dosing
FDA Approved Indications
- HIV-1 Infection: treatment in combination with other antiretroviral agents for individuals who are CCR5-tropic HIV-1 infected.
Who Shouldn't Take Maraviroc?
- Known hypersensitivity to maraviroc or any component of the formulation.
- Presence of CXCR4-tropic HIV-1, as it is ineffective against this strain.
Advice From The Pharmacist
- Take maraviroc exactly as prescribed, and do not skip doses to ensure optimal viral suppression.
- Inform your healthcare provider of any other medications you are taking, as some can interact with maraviroc.
- Regular monitoring of liver function and HIV viral load is recommended during treatment.
Side Effects of Maraviroc
Common Side Effects
- Cough
- Fever
- Rash
- Muscle pain
- Abdominal pain
Uncommon/Severe Side Effects
- Hepatotoxicity (elevated liver enzymes)
- Cardiovascular events (such as myocardial infarction)
- Allergic reactions (rash, itching, swelling)
Risks and Warnings of Maraviroc
- Hepatotoxicity: Monitor liver function tests before and during treatment.
- Increased Risk of Infection: As with all antiretrovirals, monitor for opportunistic infections due to immune suppression.
- Cardiovascular Risk: Assess cardiovascular health, particularly in patients with pre-existing conditions.
Interactions with Maraviroc
Common Drug Interactions
- CYP3A4 Inhibitors/Inducers: Maraviroc is metabolized by the CYP3A4 enzyme; thus, drugs that inhibit or induce this enzyme can significantly affect its levels.
- Other Antiretrovirals: Be aware of potential interactions with other medications used in HIV treatment.
Alternatives to Maraviroc
- Other Antiretrovirals: Other classes of HIV medications (such as integrase inhibitors, non-nucleoside reverse transcriptase inhibitors) can be used in combination therapy depending on the patient's needs and resistance profiles.
- Entry Inhibitors: Such as enfuvirtide for patients who may not respond to maraviroc.
