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Makena
Makena is a brand name for hydroxyprogesterone caproate, a synthetic form of the hormone progesterone. It is used to reduce the risk of preterm birth in women who have a history of spontaneous preterm delivery. Makena works by helping to maintain pregnancy and supporting the uterine lining.
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Frequently Asked Questions
How quickly does Makena work?
Makena begins to work gradually; its effectiveness in preventing preterm birth is assessed over the course of treatment.
Can I take Makena with food?
Yes, Makena can be taken with or without food, as it is administered via injection.
What should I do if I miss a dose?
If you miss a dose, contact your healthcare provider to discuss the best course of action, especially regarding the timing of the next dose.
Are there any dietary restrictions while using Makena?
There are no specific dietary restrictions associated with the use of Makena.
Is Makena safe during pregnancy?
Makena is specifically indicated for use during pregnancy to reduce the risk of preterm birth in at-risk women, but any concerns should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Makena Work?
Hydroxyprogesterone caproate acts on progesterone receptors in the body, helping to stabilize the uterine lining and prevent contractions. By maintaining adequate levels of progesterone, it helps to reduce the risk of premature labor.
Common Dosages
- Injection: 250 mg/mL in a pre-filled syringe for intramuscular injection.
Typical Dosing
- The usual recommended dose is 250 mg administered intramuscularly once a week, starting as early as the 16th week of pregnancy and continuing until the 37th week or delivery, whichever comes first.
Typical Dosing
FDA Approved Indications
- Prevention of Preterm Birth: to reduce the risk of preterm birth in women with a history of spontaneous preterm delivery.
Who Shouldn't Take Makena?
- Known hypersensitivity to hydroxyprogesterone or any component of the formulation.
- History of hormone-sensitive cancers, such as breast cancer.
- Uncontrolled high blood pressure or thrombophlebitis.
Advice From The Pharmacist
- Administer the injection intramuscularly, typically in the upper outer quadrant of the buttock.
- Rotate injection sites to minimize discomfort.
- Inform your healthcare provider of any other medications or supplements you are taking, as they may interact with Makena.
Side Effects of Makena
Common Side Effects
- Injection site reactions (pain, swelling, redness)
- Headache
- Fatigue
- Nausea
Uncommon/Severe Side Effects
- Signs of blood clots (swelling, pain, or redness in the legs; sudden shortness of breath)
- Severe allergic reactions (rash, itching, difficulty breathing)
Risks and Warnings of Makena
- Thromboembolic Events: Monitor for signs of blood clots, especially in women with a history of such events.
- Hormonal Effects: Be aware of potential side effects related to hormone therapy, including mood changes or breast tenderness.
- Regular Monitoring: Regular follow-up appointments are important to assess the effectiveness and monitor for any adverse effects.
Interactions with Makena
Common Drug Interactions
- Anticoagulants: Use caution when combining with blood thinners, as progestins may increase the risk of thromboembolic events.
- Other Hormonal Treatments: Consult your healthcare provider before using other hormone-related medications.
Alternatives to Makena
- Other Progesterone Preparations: Other forms of progesterone may be considered, such as oral or vaginal preparations.
- Lifestyle Modifications: Discuss additional measures that may help reduce the risk of preterm labor with your healthcare provider.
