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Luxturna

Luxturna (voretigene neparvovec-rzyl) is a gene therapy used to treat inherited retinal dystrophy caused by mutations in the RPE65 gene, a condition that can lead to progressive vision loss and eventually blindness. It is the first FDA-approved gene therapy for an inherited condition and is specifically designed for patients with biallelic RPE65 mutations who have sufficient viable retinal cells. Luxturna works by delivering a functional copy of the RPE65 gene to retinal cells, allowing them to produce the enzyme needed for normal vision. It is used in both children and adults and offers hope for those with this rare genetic condition.

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Frequently Asked Questions

How long does it take to see results after receiving Luxturna?
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Improvements in vision may be noticeable within weeks to months after treatment. The exact timeframe varies between individuals, but gradual improvement in low-light vision and visual acuity may be observed.

How long do the effects of Luxturna last?
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The effects of Luxturna are intended to be long-lasting, as it provides a functional copy of the RPE65 gene to retinal cells. However, because retinal cells are not continually replaced, the long-term duration of the effect remains under study.

Can Luxturna reverse vision loss?
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Luxturna cannot completely reverse vision loss that has already occurred. It is most effective in slowing disease progression and improving functional vision in patients who still have viable retinal cells.

What happens if Luxturna doesn’t work?
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If Luxturna is not effective, patients should continue with other supportive therapies to manage their condition. Regular follow-ups with an ophthalmologist will help monitor vision and explore other potential treatments.

Is Luxturna covered by insurance?
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Due to its high cost, Luxturna is typically covered by specialty insurance plans or through patient assistance programs. Patients should work with their healthcare provider and insurance company to determine coverage options.

Comprehensive Drug Guide

How Does Luxturna Work?

Luxturna works by delivering a normal copy of the RPE65 gene directly to retinal cells through a modified adeno-associated virus (AAV) vector. In individuals with biallelic mutations in the RPE65 gene, these retinal cells lack the ability to produce the RPE65 enzyme, which is necessary for the visual cycle. By providing a functional version of the gene, Luxturna enables these cells to produce the enzyme, restoring the visual cycle and improving vision. The therapy specifically targets the photoreceptor cells in the retina, which are essential for processing light and maintaining visual function.

Common Dosages

  • A one-time injection per eye, with each eye treated separately, usually at least 6 days apart.

Typical Dosing

  • Luxturna is administered as a single 1.5 x 10^11 vector genomes (vg) in 0.3 mL injection into the subretinal space.
  • Each eye is treated separately, and the second eye is usually treated at least 6 days after the first.

Typical Dosing

FDA Approved Indications

  • Luxturna is FDA-approved for the treatment of inherited retinal dystrophy due to biallelic mutations in the RPE65 gene. It is indicated for patients who have enough viable retinal cells to benefit from the treatment, regardless of their age.

Who Shouldn't Take Luxturna?

  • Known hypersensitivity to any of the components of Luxturna or to the AAV vector.
  • Infections in or around the eyes, or any inflammatory conditions of the eyes at the time of treatment.

Advice From The Pharmacist

  • Pre-surgery preparation: You will receive treatment from a highly specialized ophthalmology center. Before receiving Luxturna, your healthcare provider may recommend corticosteroid therapy to reduce inflammation after the procedure.
  • Post-treatment care: After receiving Luxturna, patients should avoid activities like swimming and strenuous exercise for several days to reduce the risk of infection and ensure proper healing of the treated eye.
  • Monitoring: Regular follow-up visits will be needed to monitor the health of the eyes and assess vision improvements.
  • Side effects: Some side effects like discomfort, redness, or swelling at the site of the injection may occur, but these are typically manageable.

Side Effects of Luxturna

Common Side Effects

  • Eye redness, irritation, or discomfort
  • Cataracts
  • Increased intraocular pressure (glaucoma)
  • Retinal tears or detachment
  • Eye inflammation or infection

Uncommon/Severe Side Effects

  • Retinal detachment, which may require additional surgical interventions
  • Endophthalmitis (serious eye infection)
  • Cataracts, which may require surgical removal
  • Increased intraocular pressure, which can lead to glaucoma if not properly managed

Risks and Warnings of Luxturna

  • Retinal Detachment Risk: Luxturna is administered directly into the retina, which can carry a risk of retinal detachment. If you experience sudden vision loss or flashes of light, contact your healthcare provider immediately.
  • Cataracts: Cataract formation is a known risk, particularly due to the surgical procedure. Cataract removal surgery may be required later on.
  • Immunogenicity: The body may mount an immune response to the AAV vector, though this risk is relatively low with Luxturna. Corticosteroids are often prescribed to reduce inflammation and minimize the immune response.
  • Inflammation: Postoperative inflammation is common, but it is typically managed with corticosteroids and close monitoring.

Interactions with Luxturna

Common Drug Interactions

  • Immunosuppressive therapies: While Luxturna itself does not have known drug interactions, corticosteroids are commonly prescribed before and after the procedure to minimize inflammation, and these drugs may interact with other medications. Inform your healthcare provider of all medications you are taking.
  • Vaccinations: It is generally recommended to avoid live vaccines around the time of gene therapy to prevent potential complications.

Alternatives to Luxturna

  • Supportive therapies: Visual aids and rehabilitation programs to help individuals manage their visual impairments.
  • Clinical trials: Ongoing research into gene therapies and retinal implants for other genetic retinal diseases.