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Loestrin 1/20 (21)
Loestrin 1/20 is a combination oral contraceptive that contains ethinyl estradiol and norethindrone. It is used to prevent pregnancy and is also prescribed for the management of menstrual disorders. Loestrin 1/20 works by inhibiting ovulation, altering the menstrual cycle, and thickening cervical mucus to prevent sperm from reaching the egg.
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Frequently Asked Questions
How effective is Loestrin 1/20 at preventing pregnancy?
When taken as directed, Loestrin 1/20 is over 99% effective at preventing pregnancy.
What should I do if I miss a dose?
If you miss one active tablet, take it as soon as you remember. If you miss two or more, follow the instructions provided in the patient information leaflet or contact your healthcare provider.
Can I use Loestrin 1/20 while breastfeeding?
Consult your healthcare provider about the use of hormonal contraceptives while breastfeeding, as some may not be recommended.
Will Loestrin 1/20 affect my menstrual cycle?
Some women experience lighter periods or changes in their menstrual cycle while using Loestrin 1/20.
Is it safe to smoke while taking Loestrin 1/20?
Smoking increases the risk of serious cardiovascular side effects. It is advisable to quit smoking before starting any hormonal contraceptive.
Comprehensive Drug Guide
How Does Loestrin 1/20 (21) Work?
- Inhibition of Ovulation: Prevents the ovaries from releasing eggs.
- Thickening of Cervical Mucus: Makes it more difficult for sperm to enter the uterus.
- Alteration of the Endometrium: Changes the lining of the uterus to reduce the likelihood of implantation if fertilization does occur.
Common Dosages
- Active Tablets: 20 mcg of ethinyl estradiol and 1 mg of norethindrone.
- Inactive Tablets: 7 days of placebo tablets to complete the cycle.
Typical Dosing
- Take one active tablet daily for 21 days, followed by one inactive tablet daily for 7 days. This results in a total cycle of 28 days.
- It is important to take the tablets at the same time each day for maximum effectiveness.
Typical Dosing
FDA Approved Indications
- Prevention of Pregnancy: as an oral contraceptive.
- Regulation of Menstrual Cycles: to manage menstrual disorders such as irregular periods.
Who Shouldn't Take Loestrin 1/20 (21)?
- Known hypersensitivity to any component of the formulation.
- A history of thromboembolic disorders, stroke, or heart disease.
- Uncontrolled hypertension or significant liver disease.
- Certain cancers, such as breast cancer.
Advice From The Pharmacist
- Use a backup contraceptive method (e.g., condoms) during the first 7 days of starting Loestrin 1/20 if it is your first time using hormonal contraception.
- Inform your healthcare provider of any other medications you are taking, as some can interfere with the effectiveness of Loestrin.
- Monitor for any unusual side effects, and report them to your healthcare provider.
Side Effects of Loestrin 1/20 (21)
Common Side Effects
- Nausea
- Breast tenderness
- Headache
- Mood changes
- Spotting or breakthrough bleeding
Uncommon/Severe Side Effects
- Signs of a blood clot (swelling, pain in the legs, sudden shortness of breath).
- Severe headache or vision changes.
- Signs of liver dysfunction (jaundice, severe abdominal pain).
Risks and Warnings of Loestrin 1/20 (21)
- Cardiovascular Risk: Hormonal contraceptives can increase the risk of blood clots, especially in smokers and women over 35.
- Liver Health: Regular monitoring may be required for women with liver issues.
- Missed Doses: Be aware of what to do if you miss a dose, as this can affect contraceptive effectiveness.
Interactions with Loestrin 1/20 (21)
Common Drug Interactions
- Antibiotics: Some antibiotics may reduce the effectiveness of Loestrin 1/20.
- Antiepileptic Drugs: Certain medications for seizures can affect hormone levels.
- St. John’s Wort: This herbal supplement may decrease the effectiveness of hormonal contraceptives.
Alternatives to Loestrin 1/20 (21)
- Other Oral Contraceptives: Different formulations may be recommended based on individual health needs and side effects.
- Long-Acting Reversible Contraceptives (LARCs): Such as IUDs or implants.
- Barrier Methods: Such as condoms or diaphragms for contraception.
