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Livmarli
Livmarli is a brand name for maralixibat, a medication used to treat cholestatic pruritus (itching) associated with Alagille syndrome in pediatric patients aged 1 year and older. It is an intestinal bile acid transporter inhibitor that helps reduce the absorption of bile acids in the intestine, thereby alleviating the symptoms of itching.
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Frequently Asked Questions
How quickly does Livmarli work?
Patients may begin to notice a reduction in itching within a few days to weeks of starting treatment.
Can I take Livmarli with food?
Yes, Livmarli can be taken with or without food, but consistency in how it is taken is recommended.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Livmarli?
There are no specific dietary restrictions associated with the use of Livmarli.
Is Livmarli safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Livmarli.
Comprehensive Drug Guide
How Does Livmarli Work?
Maralixibat works by inhibiting the ileal bile acid transporter (IBAT) in the intestine. This action reduces the reabsorption of bile acids, leading to decreased bile acid levels in the circulation. By lowering bile acid concentrations, Livmarli helps alleviate pruritus associated with cholestasis.
Common Dosages
- Oral Solution: 100 mg/5 mL.
Typical Dosing
- The usual recommended starting dose is 1 mg/kg taken once daily, with the maximum dose not exceeding 20 mg per day. The dose may be adjusted based on clinical response and tolerability.
Typical Dosing
FDA Approved Indications
- Cholestatic Pruritus: treatment of pruritus due to Alagille syndrome in patients aged 1 year and older.
Who Shouldn't Take Livmarli?
- Known hypersensitivity to maralixibat or any component of the formulation.
- Severe hepatic impairment.
Advice From The Pharmacist
- Take Livmarli exactly as prescribed, and do not adjust the dose without consulting your healthcare provider.
- Monitor for any signs of adverse reactions, particularly gastrointestinal symptoms.
- Regular follow-up appointments may be necessary to assess effectiveness and adjust dosing as needed.
Side Effects of Livmarli
Common Side Effects
- Diarrhea
- Abdominal pain
- Nausea
- Vomiting
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Elevated liver enzymes
Risks and Warnings of Livmarli
- Gastrointestinal Effects: Monitor for gastrointestinal side effects, particularly in young children.
- Liver Function: Liver function tests should be monitored, as liver impairment may alter drug metabolism.
- Hydration: Ensure adequate hydration, especially if experiencing diarrhea.
Interactions with Livmarli
Common Drug Interactions
- Other Medications: Consult your healthcare provider before combining with other medications, especially those that may affect liver function or gastrointestinal motility.
Common Food Interactions
Alternatives to Livmarli
- Other Antipruritic Treatments: Consider topical antihistamines or corticosteroids for symptomatic relief of itching.
- Supportive Care: Dietary modifications or other therapies may be explored for managing cholestatic symptoms.
