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Lidocaine-Hydrocort (Perianal)

Lidocaine-Hydrocort (Perianal) is a topical medication that combines lidocaine, a local anesthetic, with hydrocortisone, a corticosteroid. This formulation is used to relieve pain, itching, and inflammation associated with various perianal conditions, such as hemorrhoids or anal fissures.



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Frequently Asked Questions

How long does it take for Lidocaine-Hydrocort to start working?
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Patients may begin to feel relief from pain and itching within 15 to 30 minutes after application.

Can I take Lidocaine-Hydrocort with other medications?
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Always consult your healthcare provider before combining Lidocaine-Hydrocort with other medications, especially topical products.

What should I do if I miss a dose of Lidocaine-Hydrocort?
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If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply extra to compensate.

Is it safe to use Lidocaine-Hydrocort during pregnancy?
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Lidocaine-Hydrocort should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.

Can Lidocaine-Hydrocort cause weight gain?
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Weight gain is not typically associated with Lidocaine-Hydrocort. Any significant changes in weight should be discussed with a healthcare provider.

Comprehensive Drug Guide

How Does Lidocaine-Hydrocort (Perianal) Work?

  • Lidocaine: Blocks sodium channels in the neuronal membrane, inhibiting the initiation and conduction of nerve impulses, which provides localized pain relief.
  • Hydrocortisone: Reduces inflammation by inhibiting the release of inflammatory mediators and suppressing the immune response, helping to alleviate swelling and discomfort.

Common Dosages

  • Topical cream or ointment: Common concentrations include lidocaine 1% to 5% and hydrocortisone 1%.

Typical Dosing

  • The usual dosing involves applying a small amount of Lidocaine-Hydrocort to the affected area 2 to 3 times daily, as needed, or as directed by a healthcare provider.

Typical Dosing

FDA Approved Indications

  • Relief of pain and itching associated with hemorrhoids and anal fissures.
  • Management of inflammation in perianal dermatitis.

Who Shouldn't Take Lidocaine-Hydrocort (Perianal)?

  • Known hypersensitivity to lidocaine, hydrocortisone, or any components of the formulation
  • Viral infections in the area of application (e.g., herpes simplex)


Advice From The Pharmacist

  • Patients should be advised to apply Lidocaine-Hydrocort only to the affected area and to wash their hands after application to prevent contact with the eyes or mucous membranes.
  • Discuss the importance of not exceeding the recommended dosage and duration of use to avoid potential side effects.
  • Encourage patients to report any signs of irritation, allergic reactions, or worsening symptoms.


Side Effects of Lidocaine-Hydrocort (Perianal)

Common Side Effects

  • Localized skin irritation
  • Redness or swelling at the application site
  • Burning or stinging sensation upon application


Uncommon/Severe Side Effects

  • Allergic reactions (anaphylaxis)
  • Systemic absorption leading to lidocaine toxicity, especially if used excessively


Risks and Warnings of Lidocaine-Hydrocort (Perianal)

  • Local Irritation: Monitor for any signs of irritation or allergic reaction, especially during initial use.
  • Caution in Infants and Young Children: Use should be under the guidance of a healthcare provider to prevent systemic absorption and toxicity.

Interactions with Lidocaine-Hydrocort (Perianal)

Common Drug Interactions

Other Topical Agents: Avoid concurrent use with other topical anesthetics or corticosteroids to reduce the risk of increased side effects.

Alternatives to Lidocaine-Hydrocort (Perianal)

  • Other Topical Treatments: Such as witch hazel or hydrocortisone alone for symptom relief.
  • Oral Medications: Oral analgesics or anti-inflammatory medications may also be considered for pain management.