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Levorphanol Tartrate
Levorphanol tartrate is an opioid analgesic used for the relief of moderate to severe pain. It is effective for managing pain in various conditions, including post-surgical pain and chronic pain in certain disorders.
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Frequently Asked Questions
How long does it take for levorphanol tartrate to start working?
Levorphanol typically begins to relieve pain within 30 to 60 minutes after oral administration, with peak effects occurring around 1 to 2 hours.
Can I take levorphanol tartrate with other medications?
Always consult your healthcare provider before combining levorphanol with other medications, especially those that may depress the central nervous system.
What should I do if I miss a dose of levorphanol tartrate?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use levorphanol tartrate during pregnancy?
Levorphanol should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can levorphanol tartrate cause weight gain?
Weight gain is not commonly reported with levorphanol. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Levorphanol Tartrate Work?
Levorphanol acts primarily on the mu-opioid receptors in the central nervous system to produce analgesic effects. It also has some activity at kappa and delta opioid receptors, contributing to its pain-relieving properties. By binding to these receptors, levorphanol alters the perception of pain and emotional response to it.
Common Dosages
Levorphanol tartrate is typically available in the following formulations:
- Tablets: Common dosages include 2 mg and 4 mg.
Typical Dosing
- The usual starting dose for adults is 2 mg to 4 mg taken orally every 6 to 8 hours as needed for pain. The dosage may be adjusted based on individual response and tolerance.
Typical Dosing
FDA Approved Indications
Management of moderate to severe pain in adults.
Who Shouldn't Take Levorphanol Tartrate?
- Known hypersensitivity to levorphanol or any components of the formulation
- Significant respiratory depression or asthma
- Paralytic ileus
Advice From The Pharmacist
- Patients should be advised to take levorphanol exactly as prescribed and to avoid increasing the dosage without consulting their healthcare provider.
- Discuss the importance of monitoring for side effects, particularly respiratory depression, especially in the elderly or those with compromised lung function.
- Inform patients about the risk of dependence and the importance of not sharing the medication with others.
Side Effects of Levorphanol Tartrate
Common Side Effects
- Drowsiness
- Dizziness
- Nausea
- Vomiting
- Constipation
Uncommon/Severe Side Effects
- Respiratory depression
- Severe allergic reactions (anaphylaxis)
- Dependency and withdrawal symptoms
Risks and Warnings of Levorphanol Tartrate
- Addiction and Abuse: Levorphanol has the potential for abuse, and patients should be monitored for signs of addiction or misuse.
- Respiratory Risks: Caution is advised in patients with a history of respiratory issues, and monitoring of respiratory function is important during treatment.
Interactions with Levorphanol Tartrate
Common Drug Interactions
- Other CNS Depressants: Caution is advised when used with other central nervous system depressants (e.g., benzodiazepines, alcohol) due to the increased risk of sedation and respiratory depression.
- MAO Inhibitors: Use of levorphanol within 14 days of stopping an MAO inhibitor can lead to severe side effects.
Alternatives to Levorphanol Tartrate
- Other Opioids: Such as morphine or hydromorphone for pain management.
- Non-Opioid Analgesics: Such as NSAIDs or acetaminophen for mild to moderate pain.
