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Levo-T
Levo-T (levothyroxine sodium) is a synthetic form of the thyroid hormone thyroxine (T4). It is used primarily for the treatment of hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. Levo-T helps restore normal hormone levels, thereby supporting metabolism, growth, and development.
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Frequently Asked Questions
How long does it take for Levo-T to work?
Patients may begin to notice improvements in symptoms of hypothyroidism within 2 to 4 weeks after starting treatment.
Can I take Levo-T with other medications?
Always consult your healthcare provider before combining Levo-T with other medications, especially those that affect thyroid function.
What should I do if I miss a dose of Levo-T?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Levo-T during pregnancy?
Levo-T is considered safe during pregnancy and is often required for proper fetal development; consult a healthcare provider for individualized management.
Can Levo-T cause weight gain?
Weight gain is not commonly associated with Levo-T when dosed appropriately; however, any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Levo-T Work?
Levothyroxine sodium works by replacing or supplementing the deficient thyroid hormone in the body. It increases metabolic activity in various tissues, influencing growth, development, and the overall metabolism of carbohydrates, fats, and proteins.
Common Dosages
- Tablets: Common dosages include 25 mcg, 50 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, and 200 mcg.
- Oral solution: Usually 100 mcg/mL.
Typical Dosing
- The usual starting dose for adults is typically 1.6 mcg/kg of body weight per day, adjusted based on TSH levels. For elderly patients or those with heart conditions, a lower starting dose may be recommended.
Typical Dosing
FDA Approved Indications
- Treatment of hypothyroidism.
- Suppression of thyroid-stimulating hormone (TSH) in the management of certain types of thyroid cancer.
Who Shouldn't Take Levo-T?
- Known hypersensitivity to levothyroxine or any components of the formulation
- Untreated adrenal insufficiency
- Recent myocardial infarction
Advice From The Pharmacist
- Patients should be advised to take Levo-T on an empty stomach, preferably in the morning, at least 30-60 minutes before breakfast for optimal absorption.
- Discuss the importance of regular follow-up appointments to monitor thyroid function and adjust dosage as needed.
- Inform patients about potential side effects and the importance of adhering to prescribed therapy.
Side Effects of Levo-T
Common Side Effects
- Increased heart rate (tachycardia)
- Nervousness or anxiety
- Insomnia
- Weight loss
- Heat intolerance
Uncommon/Severe Side Effects
- Symptoms of hyperthyroidism (overmedication)
- Chest pain or heart palpitations
- Severe allergic reactions (anaphylaxis)
Risks and Warnings of Levo-T
- Thyroid Function Monitoring: Regular monitoring of TSH and free T4 levels is essential to ensure proper dosing and avoid over- or under-treatment.
- Cardiovascular Monitoring: Caution in patients with cardiovascular disease due to the potential for increased heart rate and blood pressure.
Interactions with Levo-T
Common Drug Interactions
- Anticoagulants: Levothyroxine may enhance the effects of anticoagulants, requiring close monitoring of INR levels.
- Calcium and Iron Supplements: These may interfere with levothyroxine absorption; patients should space dosing appropriately.
Alternatives to Levo-T
- Desiccated Thyroid: A natural thyroid hormone replacement option.
- Liothyronine (T3): Another form of thyroid hormone therapy, usually used in specific clinical situations.
