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Ledipasvir-Sofosbuvir

Ledipasvir-sofosbuvir is a combination antiviral medication used for the treatment of chronic hepatitis C virus (HCV) infection. This medication combines ledipasvir, an NS5A inhibitor, and sofosbuvir, an NS5B polymerase inhibitor, to effectively inhibit the replication of the hepatitis C virus.



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Frequently Asked Questions

How long does it take for ledipasvir-sofosbuvir to work?
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Patients may begin to see improvements in liver function and viral load within a few weeks of starting treatment, with sustained virologic response (SVR) assessed after completing the course.

Can I take ledipasvir-sofosbuvir with other medications?
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Always consult your healthcare provider before combining ledipasvir-sofosbuvir with other medications, especially those affecting liver enzymes.

What should I do if I miss a dose of ledipasvir-sofosbuvir?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Is it safe to use ledipasvir-sofosbuvir during pregnancy?
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Ledipasvir-sofosbuvir should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.

Can ledipasvir-sofosbuvir cause weight gain?
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Weight gain is not commonly associated with ledipasvir-sofosbuvir. Any significant changes in weight should be discussed with a healthcare provider.

Comprehensive Drug Guide

How Does Ledipasvir-Sofosbuvir Work?

  • Ledipasvir: Inhibits the NS5A protein, which is essential for viral replication and assembly.
  • Sofosbuvir: Inhibits the NS5B polymerase, preventing the virus from replicating its RNA.

Common Dosages

  • Tablets: Common dosage is 90 mg of ledipasvir and 400 mg of sofosbuvir.

Typical Dosing

  • The usual dosage for adults is one tablet taken orally once daily with or without food, typically for a duration of 8 to 12 wee

Typical Dosing

FDA Approved Indications

Treatment of chronic hepatitis C virus infection in adults and certain pediatric patients.

Who Shouldn't Take Ledipasvir-Sofosbuvir?

  • Known hypersensitivity to ledipasvir, sofosbuvir, or any components of the formulation
  • Severe hepatic impairment (Child-Pugh Class C)


Advice From The Pharmacist

  • Patients should be advised to take ledipasvir-sofosbuvir exactly as prescribed and to complete the full course of treatment.
  • Discuss the importance of regular follow-up appointments to monitor liver function and viral load.
  • Inform patients about potential side effects and the importance of reporting any unusual symptoms.


Side Effects of Ledipasvir-Sofosbuvir

Common Side Effects

  • Fatigue
  • Headache
  • Nausea
  • Diarrhea


Uncommon/Severe Side Effects

  • Severe allergic reactions (anaphylaxis)
  • Liver function abnormalities


Risks and Warnings of Ledipasvir-Sofosbuvir

  • Hepatitis B Reactivation: Patients with a history of hepatitis B virus infection should be monitored, as reactivation may occur.
  • Drug Interactions: Caution is advised when used with other medications that may affect liver enzymes.

Interactions with Ledipasvir-Sofosbuvir

Common Drug Interactions

  • Anticonvulsants: Certain anticonvulsants may reduce the effectiveness of ledipasvir-sofosbuvir and may require dose adjustments.
  • Other Antivirals: Caution is advised when used with other hepatitis C medications to avoid increased toxicity.

Alternatives to Ledipasvir-Sofosbuvir

Other HCV Treatments: Other direct-acting antiviral combinations may be considered based on genotype and treatment history.