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LaMICtal XR
Lamictal XR (lamotrigine) is an anticonvulsant medication primarily used for the treatment of epilepsy and the management of bipolar disorder. It helps stabilize mood and prevent seizures by modulating the release of excitatory neurotransmitters in the brain.
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Frequently Asked Questions
How long does it take for Lamictal XR to start working?
It may take several weeks to notice the full benefits of Lamictal XR in managing seizures or mood stabilization.
Can I take Lamictal XR with other medications?
Always consult your healthcare provider before combining Lamictal XR with other medications, particularly anticonvulsants or medications affecting liver enzymes.
What should I do if I miss a dose of Lamictal XR?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Lamictal XR during pregnancy?
Lamictal XR should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Lamictal XR cause weight gain?
Weight gain is not commonly reported with Lamictal XR, but individual responses may vary. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does LaMICtal XR Work?
Lamotrigine works by inhibiting voltage-sensitive sodium channels, which reduces the release of excitatory neurotransmitters, thereby stabilizing neuronal membranes and preventing excessive neuronal firing that leads to seizures and mood disturbances.
Common Dosages
- Extended-release tablets: Common dosages include 100 mg, 200 mg, and 300 mg.
Typical Dosing
- The usual starting dose for adults is 25 mg once daily, which may be gradually increased based on clinical response and tolerability, up to a maximum of 400 mg per day.
Typical Dosing
FDA Approved Indications
- Adjunctive treatment of partial seizures in adults and children.
- Lennox-Gastaut syndrome.
- Maintenance treatment of bipolar disorder to delay the occurrence of mood episodes.
Who Shouldn't Take LaMICtal XR?
- Known hypersensitivity to lamotrigine or any components of the formulation
- A history of severe skin reactions to lamotrigine
Advice From The Pharmacist
- Patients should be advised to take Lamictal XR as prescribed, typically once daily.
- Inform patients about the potential for serious skin rashes, which can be life-threatening.
- Advise patients to report any signs of rash, fever, or flu-like symptoms immediately.
Side Effects of LaMICtal XR
Common Side Effects
- Dizziness
- Headache
- Nausea
- Somnolence (drowsiness)
- Insomnia
Uncommon/Severe Side Effects
- Severe skin reactions (e.g., Stevens-Johnson syndrome)
- Aseptic meningitis
- Blood dyscrasias
Risks and Warnings of LaMICtal XR
- Skin Reactions: Monitor closely for skin reactions, particularly during the first few weeks of treatment.
- Withdrawal: Sudden discontinuation of Lamictal XR can lead to increased seizure frequency; gradual tapering is recommended.
Interactions with LaMICtal XR
Common Drug Interactions
- Valproate: Increased risk of lamotrigine-related adverse effects; dosage adjustments may be necessary.
- Oral Contraceptives: Hormonal contraceptives may lower lamotrigine levels; dosage adjustments may be required during hormonal changes.
Alternatives to LaMICtal XR
- Other Anticonvulsants: Such as levetiracetam or carbamazepine for seizure management.
- Other Mood Stabilizers: Such as lithium or valproate for bipolar disorder management.
