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Lagevrio
Lagevrio, the brand name for molnupiravir, is an antiviral medication used to treat mild to moderate COVID-19 in adults who are at high risk of progressing to severe disease, including hospitalization or death. Lagevrio works by interfering with the virus's ability to replicate, thereby reducing the viral load in the body. It is typically prescribed for those who cannot take other treatments or when other treatments are unavailable.
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Frequently Asked Questions
How quickly does Lagevrio start working?
Lagevrio begins to reduce viral replication soon after it is absorbed, though improvement in symptoms may take a few days. It is important to complete the full course for maximum benefit.
Can Lagevrio be taken with other COVID-19 treatments?
Lagevrio is typically used when other treatment options, such as monoclonal antibodies or Paxlovid, are not available or appropriate. Consult your doctor for the most suitable treatment plan.
Can I take Lagevrio if I am vaccinated?
Yes, Lagevrio can be used in vaccinated individuals who develop COVID-19 and are at high risk for severe illness. However, it is not intended to replace vaccination as a preventative measure.
What should I do if I miss a dose of Lagevrio?
If you miss a dose, take it as soon as you remember, but do not double up on doses. Continue with your regular dosing schedule.
Is Lagevrio safe for long-term use?
Lagevrio is designed for short-term use, typically for 5 days. Long-term use is not recommended, and its safety for extended use has not been established.
Comprehensive Drug Guide
How Does Lagevrio Work?
Lagevrio works by incorporating itself into the RNA of the SARS-CoV-2 virus (the virus that causes COVID-19) during replication. This leads to the production of errors in the viral RNA, causing the virus to become defective and unable to replicate effectively. By reducing viral replication, Lagevrio helps lower the viral load and prevent the virus from spreading in the body, thus alleviating symptoms and reducing the severity of the disease.
Common Dosages
- 200 mg oral capsules
The typical regimen is 800 mg (four 200 mg capsules) taken twice daily for 5 days.
Typical Dosing
- For COVID-19 treatment: The recommended dosage is 800 mg (four 200 mg capsules) taken twice daily for 5 consecutive days. The capsules should be swallowed whole with or without food.
Typical Dosing
FDA Approved Indications
- Treatment of mild to moderate COVID-19 in adults who are at high risk for progression to severe COVID-19, including hospitalization or death, and for whom other treatment options are either unavailable or clinically inappropriate.
Who Shouldn't Take Lagevrio?
- Pregnancy: Lagevrio is not recommended during pregnancy due to the potential risk of harm to the fetus.
- Breastfeeding: Women who are breastfeeding should not use Lagevrio or should discontinue breastfeeding during treatment and for a few days after the last dose.
- Known hypersensitivity or allergic reactions to molnupiravir or any component of the medication.
Advice From The Pharmacist
- Take Lagevrio exactly as prescribed: Complete the full 5-day course, even if you start feeling better. Stopping the medication early can result in the virus not being fully eliminated.
- Do not crush, chew, or open the capsules. Swallow them whole with or without food.
- Lagevrio should be used only under the guidance of a healthcare provider, and it is intended for patients at high risk of severe COVID-19 outcomes.
- Avoid pregnancy while taking Lagevrio and for 4 days after completing the treatment. Women of childbearing age should use effective contraception during treatment.
- Men with partners who could become pregnant should use reliable contraception during treatment and for at least 3 months after the last dose of Lagevrio.
- Store at room temperature and keep the capsules in their original packaging until ready to use.
Side Effects of Lagevrio
Common Side Effects
- Diarrhea
- Nausea
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Allergic reactions (e.g., rash, swelling, difficulty breathing)
- Fetal harm if taken during pregnancy
Risks and Warnings of Lagevrio
- Pregnancy Risk: Lagevrio should not be used during pregnancy due to the potential risk of fetal harm. Women of childbearing potential should use effective contraception during and for 4 days after completing treatment. Men with partners who could become pregnant should use contraception for 3 months after treatment.
- Drug Resistance: There is a risk of the virus developing resistance if Lagevrio is not taken as prescribed. It is crucial to complete the entire 5-day course to reduce the likelihood of resistance.
- Lagevrio is not a substitute for vaccination: While Lagevrio can help treat COVID-19, it is not a replacement for the COVID-19 vaccine. Vaccination remains an essential tool in preventing infection.
Interactions with Lagevrio
Common Drug Interactions
- There are no significant drug interactions reported for Lagevrio, but it is important to inform your healthcare provider of all medications, including over-the-counter drugs, supplements, and herbal products.
Alternatives to Lagevrio
- Paxlovid (nirmatrelvir/ritonavir): Another antiviral therapy for COVID-19, approved for emergency use in high-risk patients.
- Remdesivir (Veklury): An antiviral drug given intravenously, used to treat hospitalized COVID-19 patients.
- Monoclonal antibodies (e.g., sotrovimab, casirivimab/imdevimab): Used for treating mild to moderate COVID-19 in high-risk patients, though their availability may vary based on variant resistance.
