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Kevzara
Kevzara (sarilumab) is a monoclonal antibody used primarily for the treatment of moderate to severe rheumatoid arthritis in adults. It belongs to a class of medications known as interleukin-6 (IL-6) receptor antagonists, which help reduce inflammation and slow disease progression. By blocking the action of IL-6, a protein that contributes to the inflammatory process, Kevzara helps improve symptoms such as joint pain, swelling, and stiffness, allowing patients to better manage their condition.
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Frequently Asked Questions
How long does it take for Kevzara to start working?
Many patients may begin to see improvements within a few weeks, but it can take up to 12 weeks or longer for the full benefits to be realized.
Can I receive vaccinations while on Kevzara?
Live vaccines should be avoided during treatment with Kevzara. Discuss any necessary vaccinations with your healthcare provider.
What should I do if I miss a dose of Kevzara?
If you miss a dose, administer it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and return to your regular schedule. Do not double up on doses.
Is Kevzara safe for long-term use?
Studies have shown that Kevzara is generally safe for long-term use, but regular monitoring by your healthcare provider is essential to ensure ongoing safety and effectiveness.
Can Kevzara cause weight gain?
Weight gain is not commonly reported with Kevzara, but if you notice significant changes in weight, discuss this with your healthcare provider.
Comprehensive Drug Guide
How Does Kevzara Work?
Kevzara works by selectively binding to the IL-6 receptor, blocking the action of IL-6, which plays a key role in the inflammatory response associated with rheumatoid arthritis. By inhibiting this receptor, Kevzara helps reduce the production of inflammatory markers, leading to decreased joint inflammation and improved symptoms for patients.
Common Dosages
- Subcutaneous Injection: 150 mg and 200 mg in pre-filled syringes or pens
Typical Dosing
- The typical starting dose of Kevzara is 200 mg administered subcutaneously every two weeks.
- If needed, the dose may be reduced to 150 mg based on clinical response and tolerability.
Typical Dosing
FDA Approved Indications
- Moderate to severe rheumatoid arthritis in adults who have had an inadequate response to one or more disease-modifying antirheumatic drugs (DMARDs)
Who Shouldn't Take Kevzara?
- Known hypersensitivity to sarilumab or any components of the formulation
- Active infections, especially tuberculosis (TB) or severe infections
- A history of gastrointestinal perforations
Advice From The Pharmacist
- Kevzara is administered via subcutaneous injection; patients should receive proper training on how to self-inject or have it administered by a healthcare professional.
- Monitor for signs of infection, as Kevzara may increase the risk of serious infections.
- Regular blood tests may be required to monitor liver function and blood cell counts during treatment.
- Store Kevzara in the refrigerator and allow it to reach room temperature before injecting. Do not shake the syringe or pen.
Side Effects of Kevzara
Common Side Effects
- Injection site reactions (redness, swelling, itching)
- Upper respiratory infections
- Headache
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Increased risk of infections, including tuberculosis
- Liver enzyme elevations
Risks and Warnings of Kevzara
- Infection Risk: Kevzara may suppress the immune system, increasing the risk of infections. Patients should be monitored for symptoms such as fever, cough, or unusual fatigue.
- Gastrointestinal Perforation: There is a risk of gastrointestinal perforation, particularly in patients with a history of diverticulitis. Patients should be cautious and report any severe abdominal pain.
- Liver Function: Regular monitoring of liver function tests is necessary, as Kevzara can cause elevations in liver enzymes.
Interactions with Kevzara
Common Drug Interactions
- Immunosuppressants: Using Kevzara in combination with other immunosuppressive therapies may increase the risk of infections.
- Vaccinations: Live vaccines should be avoided during treatment with Kevzara, as they may not be effective and could pose a risk of infection.
Alternatives to Kevzara
- Other IL-6 inhibitors: Such as tocilizumab, which is also used for rheumatoid arthritis.
- Tumor necrosis factor (TNF) inhibitors: Including adalimumab and etanercept, which target different inflammatory pathways.
- DMARDs: Traditional DMARDs like methotrexate or sulfasalazine can also be effective in managing rheumatoid arthritis.
