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KelaRx

KelaRx is the brand name for ketorolac tromethamine, a nonsteroidal anti-inflammatory drug (NSAID) used for the short-term management of moderate to severe pain. It is commonly prescribed for postoperative pain, acute pain, and in some cases, as an alternative to opioids. KelaRx works by inhibiting the enzymes involved in the production of prostaglandins, which are responsible for inflammation, pain, and fever.

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Frequently Asked Questions

How quickly does KelaRx work?
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KelaRx typically starts to relieve pain within 30 to 60 minutes after administration, depending on the route of administration.

Can I take KelaRx with food?
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Yes, KelaRx can be taken with food to minimize gastrointestinal upset, especially if you experience nausea.

What should I do if I miss a dose of KelaRx?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and return to your regular schedule. Do not double up on doses.

Is KelaRx safe during pregnancy?
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KelaRx is generally not recommended during pregnancy, particularly in the third trimester, due to potential risks to the fetus. Consult your healthcare provider for personalized advice.

Can I drink alcohol while taking KelaRx?
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It is advisable to avoid alcohol while taking KelaRx, as it can increase the risk of gastrointestinal bleeding and other side effects.

Comprehensive Drug Guide

How Does KelaRx Work?

Ketorolac works by blocking the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are crucial for the conversion of arachidonic acid to prostaglandins, which promote inflammation, pain, and fever. By inhibiting COX enzymes, KelaRx reduces the production of prostaglandins, leading to decreased inflammation and pain relief.

Common Dosages

  • Injectable solution: Typically, the initial dose is 30 mg given intramuscularly or intravenously, followed by 15 mg every 6 hours as needed.
  • Oral tablets: The usual dosage is 10 mg taken every 4 to 6 hours as needed for pain, not to exceed 40 mg/day.
  • Ophthalmic solution: Administered as 1 drop into the affected eye(s) every 6 to 8 hours as needed.

Typical Dosing

  • For postoperative pain: Inject 30 mg initially, then 15 mg every 6 hours as needed.
  • For oral pain management: Take 10 mg every 4 to 6 hours as needed, not exceeding 40 mg/day.

Typical Dosing

FDA Approved Indications

  • Short-term management of moderate to severe pain (usually not to exceed 5 days for the oral form)
  • Postoperative pain management
  • Ocular inflammation and pain (with the ophthalmic solution)

Off-Label Uses


Pediatric Dosing


Who Shouldn't Take KelaRx?

  • Known hypersensitivity to ketorolac or any components of the formulation.
  • History of asthma, urticaria, or other allergic reactions after taking NSAIDs or aspirin.
  • Active peptic ulcer disease or gastrointestinal bleeding.
  • Severe renal impairment.
  • Labor or delivery (due to potential effects on the fetal cardiovascular system).

Advice From The Pharmacist

  • Follow the prescribed dosage: Adhere strictly to the recommended dose and duration to minimize the risk of side effects.
  • Avoid alcohol: Alcohol can increase the risk of gastrointestinal bleeding and should be avoided while taking KelaRx.
  • Monitor for side effects: Common side effects include nausea, vomiting, headache, and gastrointestinal discomfort. Report any severe reactions, such as blood in stools or severe abdominal pain, to your healthcare provider immediately.
  • Use caution with other medications: Inform your healthcare provider about all medications you are taking to avoid potential drug interactions, particularly other NSAIDs or anticoagulants.

Side Effects of KelaRx

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Dizziness
  • Abdominal pain

Uncommon/Severe Side Effects

  • Gastrointestinal bleeding or ulcers
  • Kidney problems (e.g., decreased urine output)
  • Severe allergic reactions (e.g., rash, itching, swelling, difficulty breathing)

Risks and Warnings of KelaRx

  • Gastrointestinal Risks: KelaRx can increase the risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation, especially in older adults or those with a history of gastrointestinal issues.
  • Renal Function: Monitor kidney function, particularly in patients with preexisting renal impairment or those taking other medications affecting renal function.
  • Cardiovascular Risks: Long-term use of NSAIDs may increase the risk of cardiovascular events. Patients with cardiovascular disease should use KelaRx with caution.

Interactions with KelaRx

Common Drug Interactions

  • Other NSAIDs: Combining with other NSAIDs increases the risk of gastrointestinal side effects.
  • Anticoagulants: Concurrent use with blood thinners (e.g., warfarin) can increase the risk of bleeding.
  • Diuretics: Ketorolac can reduce the effectiveness of diuretics and increase the risk of kidney damage.

Alternatives to KelaRx

  • Other NSAIDs: Such as ibuprofen or naproxen, for pain management.
  • Acetaminophen (Tylenol): An alternative for pain relief without the gastrointestinal risks associated with NSAIDs.
  • Opioids: For severe pain management in cases where NSAIDs are ineffective or contraindicated.