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Jynneos
Jynneos is a live, attenuated vaccine that provides protection against monkeypox and smallpox. It is particularly important for individuals who may be at risk of exposure to these viruses, including healthcare workers and certain high-risk populations. Jynneos is designed to induce a robust immune response to help prevent infection and disease caused by both monkeypox and smallpox viruses.
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Frequently Asked Questions
How effective is Jynneos?
Jynneos has shown strong immune responses in clinical trials and is expected to provide effective protection against monkeypox and smallpox in those at risk.
Can I get Jynneos if I am sick?
If you are moderately to severely ill, it is generally recommended to postpone vaccination until recovery. Consult your healthcare provider for specific guidance.
What should I do if I experience side effects?
Mild side effects are common and usually resolve on their own. However, if you experience severe reactions or signs of an allergic reaction, seek immediate medical attention.
Is Jynneos safe during pregnancy?
The safety of Jynneos during pregnancy has not been established. Discuss with your healthcare provider to weigh the risks and benefits.
How long does it take for the vaccine to provide protection?
Protection from Jynneos typically begins within a few weeks after vaccination. For optimal immunity, follow the dosing schedule recommended by your healthcare provider.
Comprehensive Drug Guide
How Does Jynneos Work?
Jynneos works by introducing a modified, weakened form of the vaccinia virus (related to the smallpox virus) into the body. This stimulates the immune system to produce antibodies and activate immune cells, thereby preparing the body to fight off actual infections caused by the monkeypox or smallpox viruses. By generating an immune response, the vaccine reduces the likelihood of severe illness or complications from these diseases.
Common Dosages
- 1 dose administered subcutaneously. A second dose may be recommended for certain populations or based on public health guidelines.
Typical Dosing
- For monkeypox and smallpox prevention: Administer 1 dose of Jynneos subcutaneously. A second dose may be given 28 days after the first dose for individuals at higher risk or according to specific health recommendations.
Typical Dosing
FDA Approved Indications
- Prevention of monkeypox and smallpox in adults and children at high risk of exposure to these viruses.
Who Shouldn't Take Jynneos?
- Severe allergic reactions to any components of the vaccine, including eggs or neomycin.
- Immunocompromised states: Individuals with weakened immune systems should avoid this vaccine, as it is a live virus vaccine.
- Pregnancy: Pregnant individuals should consult their healthcare provider, as the vaccine is not recommended during pregnancy unless the benefits outweigh the risks.
Advice From The Pharmacist
- Follow the vaccination schedule: Ensure to receive the vaccine as recommended by your healthcare provider, particularly if a second dose is indicated.
- Monitor for side effects: Common side effects include pain at the injection site, fever, fatigue, and headache. Report any severe allergic reactions or unusual symptoms to your healthcare provider.
- Inform your healthcare provider: Prior to vaccination, inform them about any allergies, current medications, and medical history, particularly related to immune system health.
- Store Jynneos correctly: Ensure the vaccine is stored at the appropriate temperature and away from light before administration.
Side Effects of Jynneos
Common Side Effects
- Injection site reactions (pain, redness, swelling)
- Fever
- Fatigue
- Headache
- Muscle aches
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Myocarditis or pericarditis: Rare but possible inflammatory heart conditions.
Risks and Warnings of Jynneos
- Immunocompromised Individuals: Special care should be taken to avoid vaccination in those with weakened immune systems, as they may be at increased risk for complications.
- Pregnancy and Breastfeeding: Vaccination should be discussed with a healthcare provider if the individual is pregnant, planning to become pregnant, or breastfeeding.
- Public Health Guidance: Follow local health guidelines regarding vaccination, especially during outbreaks or exposure events.
Interactions with Jynneos
Common Drug Interactions
- Jynneos has minimal known interactions, but patients should inform their healthcare provider about all medications and vaccines they are taking. Live vaccines should not typically be administered simultaneously with other live vaccines unless otherwise directed.
Alternatives to Jynneos
- Other Vaccines: There are no direct alternatives to Jynneos for monkeypox and smallpox prevention, as it is a specialized vaccine. Smallpox vaccination (historically) used the vaccinia virus; however, Jynneos is a more modern alternative.
- Post-exposure prophylaxis: In certain cases, vaccination may be offered after exposure to monkeypox or smallpox to reduce the likelihood of disease development.
