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Jatenzo
Jatenzo is the brand name for testosterone undecanoate, an androgen medication used for the treatment of hypogonadism in adult men. Hypogonadism is a condition characterized by insufficient testosterone production, which can lead to symptoms such as fatigue, depression, low libido, and reduced muscle mass. Jatenzo is indicated for men who have low testosterone levels confirmed by laboratory testing and are experiencing symptoms associated with testosterone deficiency.
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Frequently Asked Questions
How quickly does Jatenzo work?
Patients may start to notice improvements in symptoms related to low testosterone levels within a few weeks of starting treatment, but it can take longer for maximum benefits.
Can I take Jatenzo if I am pregnant or breastfeeding?
Jatenzo is contraindicated in pregnancy and breastfeeding due to the potential for harm to the fetus or infant. Women should avoid exposure to the medication.
What should I do if I miss a dose of Jatenzo?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can I drink alcohol while taking Jatenzo?
While moderate alcohol consumption may not significantly affect testosterone levels, excessive alcohol intake should be avoided as it can impact overall health and hormonal balance.
Will I need to undergo regular testing while on Jatenzo?
Yes, regular monitoring of testosterone levels, hematocrit, and PSA levels is important to ensure the safety and effectiveness of treatment. Your healthcare provider will schedule these evaluations as needed.
Comprehensive Drug Guide
How Does Jatenzo Work?
Testosterone undecanoate is a synthetic derivative of testosterone. It works by mimicking the action of natural testosterone in the body. Once absorbed, it binds to androgen receptors in various tissues, leading to biological effects such as increased muscle mass, improved libido, enhanced mood, and other masculinizing effects. The undecanoate ester allows for a longer duration of action compared to other forms of testosterone.
Common Dosages
- Initial dose: 158 mg (two 79 mg capsules) taken orally twice daily with food.
- The dosage may be adjusted based on individual response and testosterone levels, with the maximum recommended dose being 396 mg daily.
Typical Dosing
- For hypogonadism: Start with 158 mg (two capsules) taken twice daily with meals. After assessment of testosterone levels and symptom improvement, dosage may be adjusted.
Typical Dosing
FDA Approved Indications
- Treatment of testosterone deficiency (hypogonadism) in adult males, indicated by low testosterone levels and associated clinical symptoms.
Who Shouldn't Take Jatenzo?
- Known hypersensitivity to testosterone undecanoate or any components of the formulation.
- Breast cancer or prostate cancer in men.
- Pregnancy: Jatenzo is contraindicated in women due to the risk of virilization of the female fetus.
- Severe liver disease.
Advice From The Pharmacist
- Follow the prescribed dosage: Adhere strictly to the recommended dose and duration to avoid potential side effects and ensure effectiveness.
- Take with food: Jatenzo should be taken with food to enhance absorption.
- Monitor for side effects: Common side effects may include acne, changes in mood, increased hair growth, and fluid retention. Report any severe or unusual symptoms to your healthcare provider.
- Regular follow-up: Routine monitoring of testosterone levels, hematocrit, and prostate-specific antigen (PSA) levels is essential for safety and efficacy during treatment.
- Store Jatenzo at room temperature, away from moisture and heat, and keep it out of reach of children.
Side Effects of Jatenzo
Common Side Effects
- Acne
- Weight gain
- Increased aggression or mood changes
- Headache
- Nausea
Uncommon/Severe Side Effects
- Cardiovascular events: Increased risk of heart attack or stroke, especially in older adults or those with preexisting cardiovascular conditions.
- Hepatotoxicity: Monitor liver function tests as testosterone can impact liver health.
- Sleep apnea: Worsening of existing sleep apnea may occur.
Risks and Warnings of Jatenzo
- Cardiovascular Risks: Patients with a history of heart disease or stroke should be closely monitored for cardiovascular events while taking Jatenzo.
- Prostate Health: Regular monitoring of PSA levels is essential to assess for potential prostate issues, including cancer.
- Hormonal Imbalances: Testosterone therapy can lead to increased estrogen levels, resulting in gynecomastia or other hormonal side effects.
Interactions with Jatenzo
Common Drug Interactions
- Anticoagulants: Testosterone can affect the metabolism of blood thinners, necessitating closer monitoring of coagulation levels.
- Corticosteroids: Concurrent use may enhance the effects of corticosteroids and increase the risk of side effects.
Alternatives to Jatenzo
- Other testosterone formulations: Such as testosterone enanthate, testosterone cypionate, or testosterone pellets, which may offer different administration routes (injection or implant).
- Transdermal testosterone products: Such as patches or gels for those who prefer non-injection methods.
