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Intelence
Intelence (generic name: etravirine) is an antiretroviral medication used in the treatment of HIV-1 infection in adults and children over the age of 6 years. It belongs to the class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). Intelence is typically used in combination with other antiretroviral agents to help suppress viral load and improve immune function in patients with HIV.
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Frequently Asked Questions
How long does it take for Intelence to work?
Patients may begin to see improvements in viral load within a few weeks, but optimal effects may take several months.
Can I take Intelence while pregnant?
Intelence should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Intelence?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Intelence?
There are no specific dietary restrictions, but it is recommended to take Intelence with food to improve absorption.
Is Intelence safe for long-term use?
Intelence can be safe for long-term use under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in controlling HIV.
Comprehensive Drug Guide
How Does Intelence Work?
- Binding to the reverse transcriptase enzyme of HIV, preventing the conversion of viral RNA into DNA. This action inhibits viral replication.
- Unlike nucleoside analogs, etravirine interacts with the enzyme in a way that allows it to maintain activity against HIV strains that are resistant to other NNRTIs.
Common Dosages
- Etravirine: 100 mg tablets, usually taken twice daily after a meal.
Typical Dosing
- For HIV-1 infection: The recommended dose is 200 mg (two 100 mg tablets) taken twice daily with meals to enhance absorption.
Typical Dosing
FDA Approved Indications
- Treatment of HIV-1 infection in combination with other antiretroviral agents in patients with a history of treatment failure or with resistant HIV strains.
Who Shouldn't Take Intelence?
- Known hypersensitivity to etravirine or any components of the formulation.
- Concomitant use with certain medications that can lead to serious interactions, particularly those that induce CYP450 enzymes.
Advice From The Pharmacist
- Take Intelence exactly as prescribed, with food, to ensure maximum absorption and effectiveness.
- Inform your healthcare provider of all medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.
- Regular monitoring of liver function and viral load is essential to assess treatment effectiveness and safety.
Side Effects of Intelence
Common Side Effects
- Nausea
- Diarrhea
- Fatigue
- Rash
- Headache
Uncommon/Severe Side Effects
- Severe skin reactions (e.g., Stevens-Johnson syndrome)
- Liver dysfunction (indicated by jaundice or elevated liver enzymes)
- Allergic reactions (rash, itching, or swelling).
Risks and Warnings of Intelence
- Skin Reactions: Patients should be monitored for any signs of severe skin reactions or rashes, which may require discontinuation of the medication.
- Liver Health: Regular monitoring of liver function is recommended, particularly for patients with pre-existing liver conditions.
- Drug Interactions: Etravirine has the potential for significant interactions with other medications due to its effects on the CYP450 enzyme system.
Interactions with Intelence
Common Drug Interactions
- CYP450 3A4 inducers and inhibitors: Drugs that affect this enzyme can significantly alter the effectiveness and safety of Intelence.
- Hormonal contraceptives: The effectiveness of hormonal birth control may be reduced; alternative contraceptive methods should be discussed with your healthcare provider.
Alternatives to Intelence
- Other NNRTIs: Such as rilpivirine or nevirapine for HIV treatment.
- Protease inhibitors: Such as lopinavir/ritonavir (Kaletra) or darunavir for combination therapy.
- Integrase inhibitors: Such as dolutegravir, which have a different mechanism of action and may be considered in treatment regimens.
