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Incassia
Incassia is the brand name for breztri aerosphere, an inhalation aerosol containing budesonide and formoterol fumarate. It is a combination medication used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. Budesonide is a corticosteroid that reduces inflammation in the airways, while formoterol is a long-acting beta-2 adrenergic agonist (LABA) that relaxes the muscles around the airways, leading to improved airflow and breathing.
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Frequently Asked Questions
How quickly does Incassia work?
Patients may start to experience relief from symptoms within hours of using Incassia, but maximum benefit may take a few days to a week.
Can I use Incassia with other inhaled medications?
Yes, but it is essential to space doses of different inhaled medications. Consult your healthcare provider for guidance on timing and order of administration.
What should I do if I miss a dose of Incassia?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Incassia safe during pregnancy?
The safety of Incassia during pregnancy has not been fully established. Discuss with your healthcare provider if you are pregnant or planning to become pregnant.
Can I stop using Incassia if my symptoms improve?
It is important to continue using Incassia as prescribed, even if your symptoms improve. Consult your healthcare provider before making any changes to your treatment plan.
Comprehensive Drug Guide
How Does Incassia Work?
- Budesonide works by binding to glucocorticoid receptors in the lungs, resulting in reduced inflammation, swelling, and mucus production in the airways. This action helps alleviate symptoms of COPD.
- Formoterol acts by stimulating beta-2 adrenergic receptors in the bronchial smooth muscle, leading to muscle relaxation and dilation of the airways. This bronchodilation helps improve airflow and relieve symptoms of breathing difficulty.
What is Incassia Used For?
Common Dosages
- Two inhalations (each delivering 80 mcg of budesonide and 4.5 mcg of formoterol) taken twice daily (morning and evening).
Typical Dosing
- For COPD maintenance: Inhale two puffs from the inhaler in the morning and two puffs in the evening, ensuring proper technique for optimal delivery.
Typical Dosing
FDA Approved Indications
- Maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults.
Who Shouldn't Take Incassia?
- Known hypersensitivity to budesonide, formoterol, or any components of the formulation.
- Acute asthma or COPD exacerbation requiring urgent medical attention.
Advice From The Pharmacist
- Use as prescribed: Follow your healthcare provider's instructions regarding dosage and timing for optimal results.
- Proper inhaler technique: Ensure you are familiar with the correct technique for using the inhaler. If you have questions, ask your healthcare provider or pharmacist for a demonstration.
- Monitor for side effects: Common side effects may include headache, throat irritation, cough, and oral thrush. Report any severe or persistent symptoms to your healthcare provider.
- Store Incassia at room temperature, away from moisture and heat, and keep it out of reach of children.
Side Effects of Incassia
Common Side Effects
- Headache
- Throat irritation
- Cough
- Nausea
- Oral thrush (fungal infection in the mouth)
Uncommon/Severe Side Effects
- Worsening breathing problems or acute bronchospasm.
- Cardiovascular effects: Increased heart rate or palpitations.
- Allergic reactions (e.g., rash, itching, swelling, difficulty breathing).
Risks and Warnings of Incassia
- Corticosteroid-related effects: Long-term use of inhaled corticosteroids may lead to potential systemic effects, including adrenal suppression and bone density loss.
- Increased risk of pneumonia: Patients with COPD using inhaled corticosteroids may have an increased risk of pneumonia. Monitor for symptoms such as cough, fever, and increased sputum production.
- Not for acute use: Incassia is not intended for the treatment of acute bronchospasm or as a rescue inhaler. Patients should have a separate rescue medication available.
Interactions with Incassia
Common Drug Interactions
- Beta-blockers: Non-selective beta-blockers may counteract the effects of formoterol.
- CYP3A4 inhibitors: Medications that inhibit this enzyme may increase the levels of budesonide and lead to increased side effects.
Alternatives to Incassia
- Other inhaled corticosteroids: Such as fluticasone or mometasone, for similar conditions.
- Other LABAs: Such as salmeterol or indacaterol for the management of COPD.
