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Imipramine Pamoate
Imipramine Pamoate is a tricyclic antidepressant primarily used for the treatment of depression and certain anxiety disorders. It may also be prescribed for conditions such as nocturnal enuresis (bedwetting) in children. This formulation is administered as an intramuscular injection, allowing for extended release and improved compliance in patients who may have difficulty with oral medications.
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Frequently Asked Questions
How long does it take for Imipramine Pamoate to start working?
Patients may start to notice improvements in mood within a few weeks, but full therapeutic effects may take several weeks to months.
Can I take Imipramine Pamoate with other medications?
Always consult your healthcare provider before combining Imipramine with other medications, especially other antidepressants or CNS depressants.
What should I do if I miss a dose of Imipramine Pamoate?
If you miss a dose, contact your healthcare provider for guidance on when to take the next dose.
Is it safe to use Imipramine Pamoate during pregnancy?
Imipramine should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Imipramine Pamoate cause weight gain?
Weight gain is a common side effect of tricyclic antidepressants like imipramine; patients should monitor their weight and discuss any significant changes with their healthcare provider.
Comprehensive Drug Guide
How Does Imipramine Pamoate Work?
Imipramine works by inhibiting the reuptake of neurotransmitters, primarily norepinephrine and serotonin, in the brain. This action increases the availability of these neurotransmitters, which helps improve mood and alleviate symptoms of depression and anxiety.
Common Dosages
- Injectable solution: Commonly available in 75 mg/mL.
Typical Dosing
- For depression: The typical dosing may start with 25 mg to 50 mg administered intramuscularly, with adjustments made based on the patient’s response and tolerability.
- For nocturnal enuresis: The dosing may vary, typically initiated at a lower dose and adjusted as needed.
Typical Dosing
FDA Approved Indications
- Treatment of depression
- Management of nocturnal enuresis in children
Who Shouldn't Take Imipramine Pamoate?
- Known hypersensitivity to imipramine or any components of the formulation
- Acute recovery phase after a myocardial infarction
- Severe liver disease
Advice From The Pharmacist
- Patients should be informed about the importance of adherence to the prescribed dosing schedule and to report any worsening of symptoms.
- Monitor for side effects, including sedation, weight gain, and potential cardiac effects.
- Advise patients about the possibility of drowsiness and to avoid activities requiring alertness until they know how the medication affects them.
Side Effects of Imipramine Pamoate
Common Side Effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
- Weight gain
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Arrhythmias (irregular heartbeat)
- Increased risk of suicidal thoughts or behaviors, especially in younger patients
Risks and Warnings of Imipramine Pamoate
- Cardiovascular Risk: Monitor patients for signs of heart problems, especially those with pre-existing conditions.
- Suicidal Thoughts: Regularly assess for any increase in suicidal thoughts or behaviors, particularly during the initial treatment phase or when doses are changed.
- Withdrawal Symptoms: Advise patients not to abruptly discontinue the medication, as this can lead to withdrawal symptoms.
Interactions with Imipramine Pamoate
Common Drug Interactions
- MAO Inhibitors: Concomitant use can lead to serious adverse effects and should be avoided.
- CNS Depressants: Caution is advised when combining Imipramine with other medications that cause sedation or respiratory depression.
Alternatives to Imipramine Pamoate
- Other Antidepressants: Such as selective serotonin reuptake inhibitors (SSRIs) for treating depression and anxiety.
- Behavioral Therapies: For managing nocturnal enuresis, especially in children.
