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Imcivree
Imcivree (generic name: setmelanotide) is a prescription medication used for the treatment of obesity caused by specific genetic conditions. It is primarily indicated for individuals with POMC deficiency, LEPR deficiency, or MC4R deficiency, which are rare genetic disorders that disrupt the body’s ability to regulate appetite and energy expenditure. Imcivree acts as a melanocortin receptor agonist, helping to restore the signaling pathways involved in hunger and satiety, ultimately promoting weight loss.
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Frequently Asked Questions
How long does it take for Imcivree to work?
Patients may start to see improvements in weight management within a few weeks, but individual response times can vary.
Can Imcivree be taken during pregnancy?
Imcivree should not be taken during pregnancy unless the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Imcivree?
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Imcivree?
There are no specific dietary restrictions, but maintaining a healthy diet and engaging in regular physical activity is important for effective weight management.
Is Imcivree safe for long-term use?
Imcivree can be safe for long-term use under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in managing obesity.
Comprehensive Drug Guide
How Does Imcivree Work?
- Reduce appetite: By influencing the pathways that control hunger signals, Imcivree helps decrease the desire to eat.
- Increase energy expenditure: It promotes the body's ability to burn calories more effectively.
Common Dosages
- Setmelanotide: Starting dose is usually 1 mg injected subcutaneously once daily. The dosage may be adjusted based on individual response and tolerability, typically up to a maximum of 2 mg per day.
Typical Dosing
- For obesity management: Begin with 1 mg subcutaneously once daily. Based on weight loss and tolerability, the dose may be increased to 2 mg after 4 weeks.
Typical Dosing
FDA Approved Indications
- Chronic weight management in individuals aged 6 years and older with obesity due to specific genetic deficiencies, including:
- POMC deficiency
- LEPR deficiency
- MC4R deficiency
Who Shouldn't Take Imcivree?
- Known hypersensitivity to setmelanotide or any components of the formulation.
- Uncontrolled hypertension or other cardiovascular conditions that could be exacerbated by weight loss.
Advice From The Pharmacist
- Inject Imcivree subcutaneously in the abdomen, thigh, or upper arm, rotating injection sites to minimize irritation.
- Follow the dosing schedule closely, and do not adjust the dose without consulting your healthcare provider.
- Monitor for any adverse effects, particularly changes in blood pressure or mood, and report them to your healthcare provider.
Side Effects of Imcivree
Common Side Effects
- Injection site reactions (redness, swelling, itching)
- Nausea
- Fatigue
- Headache
- Increased appetite or changes in taste
Uncommon/Severe Side Effects
- Suicidal thoughts or behavior: Patients should be monitored for any significant mood changes or suicidal ideation.
Risks and Warnings of Imcivree
- Mood Changes: There is a potential risk for mood disturbances, including depression or suicidal thoughts. Patients should be monitored closely for these symptoms.
- Blood Pressure: Changes in blood pressure may occur; regular monitoring is advised, particularly in patients with a history of hypertension or cardiovascular issues.
- Not a Replacement for Lifestyle Changes: Imcivree should be used as part of a comprehensive weight management plan that includes diet and physical activity.
Interactions with Imcivree
Common Drug Interactions
- Other medications: Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, as they may interact with Imcivree.
- Hormonal treatments: Caution should be exercised when using Imcivree with other medications that affect appetite or metabolism.
Alternatives to Imcivree
- Other weight management medications: Such as orlistat or phentermine-topiramate for general obesity treatment.
- Lifestyle modifications: Behavioral therapy, dietary changes, and exercise programs are fundamental components of weight management.
- Bariatric surgery: Considered for severe obesity when other treatments have not been effective.
