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Idaran
Idaran (generic name: alendronate sodium) is a medication primarily used to treat and prevent osteoporosis in postmenopausal women and to treat osteoporosis in men. It is also indicated for the treatment of Paget's disease of bone. Idaran belongs to a class of drugs known as bisphosphonates, which work by inhibiting bone resorption, thereby increasing bone density and reducing the risk of fractures.
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Frequently Asked Questions
How long does it take for Idaran to work?
Improvements in bone mineral density may be seen within 6 to 12 months, but the full benefit of treatment can take several years.
Can Idaran be taken during pregnancy?
Idaran should not be taken during pregnancy unless absolutely necessary. Discuss with your healthcare provider for personalized advice.
What should I do if I miss a dose of Idaran?
If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and return to your regular dosing schedule. Do not double up on doses.
Are there any dietary restrictions while taking Idaran?
It is advised to avoid calcium-rich foods, beverages, and supplements close to the time you take Idaran, as these can interfere with absorption.
Is Idaran safe for long-term use?
Idaran can be safe for long-term use under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in treating osteoporosis.
Comprehensive Drug Guide
How Does Idaran Work?
- Inhibiting osteoclast activity: Osteoclasts are cells that break down bone tissue. By inhibiting their activity, alendronate reduces bone resorption.
- Increasing bone mineral density: This leads to a net gain in bone mass and strength, reducing the risk of fractures associated with osteoporosis.
Common Dosages
- Oral tablets: 5 mg, 10 mg, 35 mg, and 70 mg.
- Oral solution: 70 mg per 75 mL.
Typical Dosing
- For osteoporosis prevention and treatment: The usual dose is 10 mg taken orally once daily or 70 mg taken once weekly.
- For Paget's disease: The dose may be higher, typically starting at 40 mg daily for up to 6 months.
Typical Dosing
FDA Approved Indications
- Treatment and prevention of osteoporosis in postmenopausal women.
- Treatment of osteoporosis in men.
- Treatment of Paget's disease of bone.
Who Shouldn't Take Idaran?
- Known hypersensitivity to alendronate or any components of the formulation.
- Esophageal abnormalities that delay esophageal emptying (e.g., strictures or achalasia).
- Inability to sit or stand upright for at least 30 minutes after taking the medication.
- Hypocalcemia (low calcium levels).
Advice From The Pharmacist
- Take Idaran first thing in the morning with a full glass of water (at least 8 ounces) to enhance absorption.
- Do not lie down for at least 30 minutes after taking the medication to prevent esophageal irritation.
- Avoid taking Idaran with food, beverages (other than water), or supplements containing calcium or antacids, as these can interfere with absorption.
- Regular monitoring of bone mineral density may be recommended to assess the effectiveness of treatment.
Side Effects of Idaran
Common Side Effects
- Gastrointestinal discomfort (nausea, abdominal pain, dyspepsia)
- Esophageal irritation or ulceration
- Musculoskeletal pain
Uncommon/Severe Side Effects
- Osteonecrosis of the jaw (especially after dental procedures)
- Atypical femur fractures
- Severe allergic reactions (rash, itching, swelling, difficulty breathing)
Risks and Warnings of Idaran
- Gastrointestinal Issues: Patients with a history of esophageal problems or gastrointestinal disorders should be monitored closely.
- Bone Health: Long-term use of bisphosphonates has been associated with rare but serious side effects, including atypical fractures and osteonecrosis of the jaw.
- Dental Health: Patients should have a dental exam before starting therapy, especially if they will undergo dental procedures.
Interactions with Idaran
Common Drug Interactions
- Antacids: Antacids containing aluminum, calcium, or magnesium may reduce the absorption of alendronate; it’s advised to separate doses by at least 30 minutes.
- Other medications: Inform your healthcare provider about all medications, including supplements and over-the-counter drugs, to avoid potential interactions.
Alternatives to Idaran
- Other bisphosphonates: Such as risedronate (Actonel) or ibandronate (Boniva).
- Selective estrogen receptor modulators (SERMs): Such as raloxifene, which may be used for osteoporosis treatment.
- Parathyroid hormone: Such as teriparatide, which can stimulate bone formation.
