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Icatibant Acetate
Icatibant Acetate is a bradykinin B2 receptor antagonist used primarily for the treatment of hereditary angioedema (HAE). This condition is characterized by recurrent episodes of swelling in various body parts, including the face, extremities, gastrointestinal tract, and airway. Icatibant works by blocking the action of bradykinin, a peptide that promotes inflammation and swelling, thereby providing rapid relief from angioedema attacks.
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Frequently Asked Questions
How quickly does Icatibant Acetate work?
Icatibant typically provides relief from HAE attack symptoms within 1 to 2 hours after administration.
Can I use Icatibant Acetate with other medications?
Always consult your healthcare provider before combining Icatibant Acetate with other medications, especially those for treating angioedema or other antihistamines.
What should I do if I miss a dose of Icatibant Acetate?
catibant is used as needed for acute attacks. If an attack occurs and you have missed a dose, administer it as soon as possible.
Is it safe to use Icatibant Acetate during pregnancy?
Icatibant Acetate should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Icatibant Acetate cause weight gain?
Weight gain is not a common side effect of Icatibant Acetate, but any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Icatibant Acetate Work?
Icatibant Acetate specifically inhibits the bradykinin B2 receptor, which prevents bradykinin from exerting its effects on blood vessels, reducing vascular permeability and thereby alleviating the symptoms of swelling associated with angioedema.
Common Dosages
- Injection: Typically provided as a 30 mg/3 mL solution for subcutaneous use.
Typical Dosing
- The recommended dose for treating acute attacks of HAE is 30 mg administered subcutaneously.
- If symptoms persist, a second dose may be given after 6 hours, but the total daily dosage should not exceed 60 mg.
Typical Dosing
FDA Approved Indications
- Acute attacks of hereditary angioedema (HAE) in adults and adolescents.
Who Shouldn't Take Icatibant Acetate?
- Known hypersensitivity to icatibant or any components of the formulation
- History of angioedema unrelated to hereditary angioedema
Advice From The Pharmacist
- Icatibant should be administered as soon as an attack of angioedema is recognized for optimal effectiveness.
- Patients should be instructed on the proper technique for subcutaneous injection, including rotation of injection sites.
- It is important for patients to have a plan in place for managing HAE attacks and to have icatibant readily available.
Side Effects of Icatibant Acetate
Common Side Effects
- Injection site reactions (pain, redness, swelling)
- Nausea
- Diarrhea
- Abdominal pain
Uncommon/Severe Side Effects
- Allergic reactions (anaphylaxis)
- Severe gastrointestinal issues
Risks and Warnings of Icatibant Acetate
- Allergic Reactions: Monitor for signs of an allergic reaction and advise patients to seek immediate medical attention if they experience symptoms such as rash, itching, or difficulty breathing.
- Gastrointestinal Effects: Patients should be aware of the potential for gastrointestinal side effects and report severe symptoms to their healthcare provider.
Interactions with Icatibant Acetate
Common Drug Interactions
- ACE Inhibitors: Caution is advised when using icatibant in patients taking ACE inhibitors, as this combination may increase the risk of angioedema.
- Other Medications for Angioedema: Patients should inform their healthcare provider about any other medications they are taking for HAE.
Alternatives to Icatibant Acetate
- C1 Esterase Inhibitor Concentrates: Used for the prevention and treatment of HAE attacks.
- Lanadelumab: A monoclonal antibody for the prevention of HAE attacks.
- Antihistamines: May be used for symptomatic relief, but they are not effective for HAE attacks.
