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Ibsrela
Ibsrela (eluxadoline) is a prescription medication specifically approved for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults. It is designed to help manage the symptoms associated with IBS-D, including abdominal pain and diarrhea. Ibsrela works by acting on the receptors in the gut to decrease bowel contractions, thus reducing diarrhea and providing relief from pain.
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Frequently Asked Questions
How long does it take for Ibsrela to start working?
Patients may begin to notice improvement in symptoms within one week, but optimal results may take longer.
Can I take Ibsrela with other medications?
Always consult your healthcare provider before combining Ibsrela with other medications, especially those that may cause sedation or gastrointestinal effects.
What should I do if I miss a dose of Ibsrela?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is it safe to use Ibsrela during pregnancy?
Ibsrela should be used during pregnancy only if clearly needed and prescribed by a healthcare provider, as safety has not been fully established.
Can Ibsrela cause weight gain?
Weight gain is not a common side effect, but patients should monitor their weight and discuss any concerns with their healthcare provider.
Comprehensive Drug Guide
How Does Ibsrela Work?
Ibsrela works by selectively activating the mu-opioid receptors in the gut, which reduces bowel motility and enhances the tone of the anal sphincter. This action helps decrease diarrhea and alleviate abdominal pain associated with IBS-D.
Common Dosages
- Tablets: Typically available in 75 mg and 100 mg doses.
Typical Dosing
- The recommended starting dose for Ibsrela is 100 mg taken orally twice daily with food. Depending on tolerance and response, the dose may be adjusted to 75 mg twice daily.
Typical Dosing
FDA Approved Indications
- Irritable bowel syndrome with diarrhea (IBS-D) in adults.
Who Shouldn't Take Ibsrela?
- Known hypersensitivity to eluxadoline or any components of the formulation
- History of pancreatitis or a biliary obstruction
- Severe hepatic impairment
Advice From The Pharmacist
- Ibsrela should be taken with food to improve absorption and reduce the risk of gastrointestinal side effects.
- Patients should be advised to adhere to the prescribed dosing schedule and not exceed the recommended dose.
- Monitor for signs of pancreatitis (severe abdominal pain) and report any such symptoms immediately.
Side Effects of Ibsrela
Common Side Effects
- Nausea
- Constipation
- Abdominal pain
- Fatigue
Uncommon/Severe Side Effects
- Pancreatitis
- Severe allergic reactions (anaphylaxis)
Risks and Warnings of Ibsrela
- Pancreatitis Risk: Ibsrela can increase the risk of pancreatitis, particularly in patients with a history of this condition.
- Constipation: Patients should be monitored for constipation and advised to maintain adequate hydration and dietary fiber intake.
Interactions with Ibsrela
Common Drug Interactions
- Alcohol: Patients should be advised to limit or avoid alcohol, as it can exacerbate side effects like sedation and gastrointestinal disturbances.
- CNS Depressants: Use caution when combining Ibsrela with other medications that cause sedation, as it may enhance these effects.
Alternatives to Ibsrela
- Loperamide (Imodium): An over-the-counter medication for managing diarrhea.
- Rifaximin: An antibiotic that can be used for certain types of IBS.
- Probiotics: Supplements that may help improve gut health and alleviate IBS symptoms.
