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HYDROmorphone HCl-NaCl
Hydromorphone HCl-NaCl is a potent opioid analgesic used for the relief of moderate to severe pain. It is a combination of hydromorphone, which is an opioid, and sodium chloride (NaCl), which is often used to maintain isotonicity in injectable formulations. Hydromorphone is known for its effectiveness in managing pain, particularly in post-operative or cancer-related scenarios.
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Frequently Asked Questions
How quickly does Hydromorphone HCl-NaCl provide pain relief?
Pain relief is typically experienced within 15 to 30 minutes of administration, particularly when given intravenously.
How quickly does Hydromorphone HCl-NaCl provide pain relief?
Pain relief is typically experienced within 15 to 30 minutes of administration, particularly when given intravenously.
Can I take Hydromorphone HCl-NaCl while pregnant?
Consult your healthcare provider for guidance, as the use during pregnancy should be evaluated based on risks and benefits.
What should I do if I miss a dose?
If you miss a dose while using a continuous infusion or scheduled dosing, contact your healthcare provider for instructions.
Are there any specific storage instructions for Hydromorphone HCl-NaCl?
Store at room temperature, away from moisture and light. Keep out of reach of children.
Is Hydromorphone HCl-NaCl safe for long-term use?
Is Hydromorphone HCl-NaCl safe for long-term use?
Comprehensive Drug Guide
How Does HYDROmorphone HCl-NaCl Work?
Hydromorphone works by binding to the opioid receptors in the brain and spinal cord, altering the perception of pain and emotional response to pain. This action helps to alleviate pain effectively and can produce feelings of euphoria, which may contribute to its potential for misuse.
Common Dosages
- Injectable solution: Common concentrations may include 1 mg/mL or 2 mg/mL, often prepared with NaCl for isotonicity.
Typical Dosing
The typical dosing for Hydromorphone HCl-NaCl is:
- For Pain Management: Dosing is individualized based on patient needs, but initial doses for opioid-naive patients may start at 0.2 to 1 mg via slow intravenous injection every 2 to 3 hours as needed.
Typical Dosing
FDA Approved Indications
Management of moderate to severe pain where an opioid analgesic is appropriate.
Who Shouldn't Take HYDROmorphone HCl-NaCl?
- Hypersensitivity: Known hypersensitivity to hydromorphone, other opioids, or any components of the formulation.
- Severe Respiratory Depression: Should not be used in patients with significant asthma or respiratory issues.
- History of Substance Abuse: Use with caution in patients with a history of substance use disorder.
Advice From The Pharmacist
- How to Use: Hydromorphone should be administered by a qualified healthcare provider, typically via intravenous or intramuscular injection.
- Monitor for Side Effects: Patients should be monitored for signs of respiratory depression, sedation, and potential allergic reactions.
- Avoid Alcohol: Alcohol can increase the risk of serious side effects and should be avoided.
Side Effects of HYDROmorphone HCl-NaCl
Common Side Effects
- Drowsiness
- Dizziness
- Constipation
- Nausea
Uncommon/Severe Side Effects
- Respiratory depression: Symptoms like slow or difficult breathing.
- Severe allergic reactions: Such as rash, itching, or difficulty breathing.
Risks and Warnings of HYDROmorphone HCl-NaCl
- Caution with Other CNS Depressants: Concurrent use with other central nervous system depressants may enhance sedation and respiratory depression.
- Dependence and Withdrawal: Long-term use can lead to physical dependence and withdrawal symptoms upon discontinuation.
Interactions with HYDROmorphone HCl-NaCl
Common Drug Interactions
- Drug Interactions: Hydromorphone HCl-NaCl may interact with other medications that affect the central nervous system, including sedatives and certain antidepressants. Always inform your healthcare provider about all medications you are taking.
Alternatives to HYDROmorphone HCl-NaCl
- Other Opioid Analgesics: Such as morphine or oxycodone for moderate to severe pain management.
- Non-Opioid Pain Relievers: Such as acetaminophen or NSAIDs for less severe pain.
